About Protein kinase C delta type
Protein kinase C delta type (PRKCD) is a protein
from Homo sapiens identified by UniProt accession
Q05655, 676 residues long.
MolForge cross-references it against 0 known binders and
624 disease associations.
Target properties
| Protein name | Protein kinase C delta type |
|---|
| UniProt accession | Q05655 |
|---|
| Gene | PRKCD |
|---|
| Organism | Homo sapiens |
|---|
| Length | 676 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (11)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (624)
Diseases linked to this target (Open Targets).
- autoimmune lymphoproliferative syndrome · score 0.56
- acute myeloid leukemia · score 0.51
- mast-cell leukemia · score 0.47
- neoplasm · score 0.42
- systemic mastocytosis · score 0.39
- common variable immunodeficiency · score 0.39
- Mastocytosis · score 0.37
- Autosomal recessive systemic lupus erythematosus · score 0.37
- non-Hodgkins lymphoma · score 0.32
- glioblastoma multiforme · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q05655-F1 | alphafold | PREDICTED | 80.71 | — |
Amino-acid sequence (676 residues)
MAPFLRIAFN SYELGSLQAE DEANQPFCAV KMKEALSTER GKTLVQKKPT MYPEWKSTFD AHIYEGRVIQ IVLMRAAEEP VSEVTVGVSV LAERCKKNNG KAEFWLDLQP QAKVLMSVQY FLEDVDCKQS MRSEDEAKFP TMNRRGAIKQ AKIHYIKNHE FIATFFGQPT FCSVCKDFVW GLNKQGYKCR QCNAAIHKKC IDKIIGRCTG TAANSRDTIF QKERFNIDMP HRFKVHNYMS PTFCDHCGSL LWGLVKQGLK CEDCGMNVHH KCREKVANLC GINQKLLAEA LNQVTQRASR RSDSASSEPV GIYQGFEKKT GVAGEDMQDN SGTYGKIWEG SSKCNINNFI FHKVLGKGSF GKVLLGELKG RGEYFAIKAL KKDVVLIDDD VECTMVEKRV LTLAAENPFL THLICTFQTK DHLFFVMEFL NGGDLMYHIQ DKGRFELYRA TFYAAEIMCG LQFLHSKGII YRDLKLDNVL LDRDGHIKIA DFGMCKENIF GESRASTFCG TPDYIAPEIL QGLKYTFSVD WWSFGVLLYE MLIGQSPFHG DDEDELFESI RVDTPHYPRW ITKESKDILE KLFEREPTKR LGVTGNIKIH PFFKTINWTL LEKRRLEPPF RPKVKSPRDY SNFDQEFLNE KARLSYSDKN LIDSMDQSAF AGFSFVNPKF EHLLED
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