About Neuronal acetylcholine receptor subunit beta-3
Neuronal acetylcholine receptor subunit beta-3 (CHRNB3) is a protein
from Homo sapiens identified by UniProt accession
Q05901, 458 residues long.
MolForge cross-references it against 0 known binders and
43 disease associations.
Target properties
| Protein name | Neuronal acetylcholine receptor subunit beta-3 |
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| UniProt accession | Q05901 |
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| Gene | CHRNB3 |
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| Organism | Homo sapiens |
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| Length | 458 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (43)
Diseases linked to this target (Open Targets).
- cigarettes per day measurement · score 0.33
- nicotine dependence · score 0.32
- smoking behavior · score 0.31
- time to first cigarette measurement · score 0.27
- tobacco smoke exposure measurement · score 0.23
- smoking cessation · score 0.23
- lung adenocarcinoma · score 0.19
- eosinophil percentage of leukocytes · score 0.07
- gut microbiome measurement · score 0.07
- attention deficit hyperactivity disorder · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q05901-F1 | alphafold | PREDICTED | 83.33 | — |
Amino-acid sequence (458 residues)
MLPDFMLVLI VLGIPSSATT GFNSIAENED ALLRHLFQGY QKWVRPVLHS NDTIKVYFGL KISQLVDVDE KNQLMTTNVW LKQEWTDHKL RWNPDDYGGI HSIKVPSESL WLPDIVLFEN ADGRFEGSLM TKVIVKSNGT VVWTPPASYK SSCTMDVTFF PFDRQNCSMK FGSWTYDGTM VDLILINENV DRKDFFDNGE WEILNAKGMK GNRRDGVYSY PFITYSFVLR RLPLFYTLFL IIPCLGLSFL TVLVFYLPSD EGEKLSLSTS VLVSLTVFLL VIEEIIPSSS KVIPLIGEYL LFIMIFVTLS IIVTVFVINV HHRSSSTYHP MAPWVKRLFL QKLPKLLCMK DHVDRYSSPE KEESQPVVKG KVLEKKKQKQ LSDGEKVLVA FLEKAADSIR YISRHVKKEH FISQVVQDWK FVAQVLDRIF LWLFLIVSVT GSVLIFTPAL KMWLHSYH
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