Dual specificity protein phosphatase 2 (DUSP2)

About Dual specificity protein phosphatase 2

Dual specificity protein phosphatase 2 (DUSP2) is a protein from Homo sapiens identified by UniProt accession Q05923, 314 residues long. MolForge cross-references it against 0 known binders and 132 disease associations.

Target properties

Protein name	Dual specificity protein phosphatase 2
UniProt accession	Q05923
Gene	DUSP2
Organism	Homo sapiens
Length	314 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (132)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.41
Parkinson disease · score 0.31
lysosomal storage disease · score 0.31
multiple sclerosis · score 0.31
Alzheimer disease · score 0.31
pancreatic adenocarcinoma · score 0.30
thyroid gland adenocarcinoma · score 0.30
cutaneous melanoma · score 0.18
lung adenocarcinoma · score 0.18
neoplasm · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q05923-F1	alphafold	PREDICTED	90.38	—

Amino-acid sequence (314 residues)

MGLEAARELE CAALGTLLRD PREAERTLLL DCRPFLAFCR RHVRAARPVP WNALLRRRAR GPPAAVLACL LPDRALRTRL VRGELARAVV LDEGSASVAE LRPDSPAHVL LAALLHETRA GPTAVYFLRG GFDGFQGCCP DLCSEAPAPA LPPTGDKTSR SDSRAPVYDQ GGPVEILPYL FLGSCSHSSD LQGLQACGIT AVLNVSASCP NHFEGLFRYK SIPVEDNQMV EISAWFQEAI GFIDWVKNSG GRVLVHCQAG ISRSATICLA YLMQSRRVRL DEAFDFVKQR RGVISPNFSF MGQLLQFETQ VLCH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards