Homeobox protein engrailed-1 (EN1)

About Homeobox protein engrailed-1

Homeobox protein engrailed-1 (EN1) is a protein from Homo sapiens identified by UniProt accession Q05925, 392 residues long. MolForge cross-references it against 0 known binders and 364 disease associations.

Target properties

Protein name	Homeobox protein engrailed-1
UniProt accession	Q05925
Gene	EN1
Organism	Homo sapiens
Length	392 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (364)

Diseases linked to this target (Open Targets).

heel bone mineral density · score 0.49
endove syndrome, limb-brain type · score 0.48
bone quantitative ultrasound measurement · score 0.48
bone density · score 0.45
neurodegenerative disease · score 0.35
waist-hip ratio · score 0.34
femoral neck bone mineral density · score 0.32
BMI-adjusted waist-hip ratio · score 0.31
hair color · score 0.29
systemic lupus erythematosus · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q05925-F1	alphafold	PREDICTED	56.54	—

Amino-acid sequence (392 residues)

MEEQQPEPKS QRDSALGAAA AATPGGLSLS LSPGASGSSG SGSDGDSVPV SPQPAPPSPP AAPCLPPLAH HPHLPPHPPP PPPQHLAAPA HQPQPAAQLH RTTNFFIDNI LRPDFGCKKE QPPPQLLVAA AARGGAGGGG RVERDRGQTA AGRDPVHPLG TRAPGAASLL CAPDANCGPP DGSQPAAAGA GASKAGNPAA AAAAAAAAVA AAAAAAAAKP SDTGGGGSGG GAGSPGAQGT KYPEHGNPAI LLMGSANGGP VVKTDSQQPL VWPAWVYCTR YSDRPSSGPR TRKLKKKKNE KEDKRPRTAF TAEQLQRLKA EFQANRYITE QRRQTLAQEL SLNESQIKIW FQNKRAKIKK ATGIKNGLAL HLMAQGLYNH STTTVQDKDE SE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards