About Folylpolyglutamate synthase, mitochondrial
Folylpolyglutamate synthase, mitochondrial (FPGS) is a protein
from Homo sapiens identified by UniProt accession
Q05932, 587 residues long.
MolForge cross-references it against 0 known binders and
56 disease associations.
Target properties
| Protein name | Folylpolyglutamate synthase, mitochondrial |
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| UniProt accession | Q05932 |
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| Gene | FPGS |
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| Organism | Homo sapiens |
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| Length | 587 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (56)
Diseases linked to this target (Open Targets).
- bone quantitative ultrasound measurement · score 0.05
- hyper-IgM syndrome type 3 · score 0.04
- acute lymphoblastic leukemia · score 0.04
- Hodgkins lymphoma · score 0.04
- classic Hodgkin lymphoma · score 0.04
- Waldenstrom macroglobulinemia · score 0.04
- immune deficiency, familial variable · score 0.04
- hyper-IgM syndrome type 2 · score 0.04
- hyper-IgM syndrome type 5 · score 0.04
- immunodeficiency, common variable, 14 · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q05932-F1 | alphafold | PREDICTED | 82.28 | — |
Amino-acid sequence (587 residues)
MSRARSHLRA ALFLAAASAR GITTQVAARR GLSAWPVPQE PSMEYQDAVR MLNTLQTNAG YLEQVKRQRG DPQTQLEAME LYLARSGLQV EDLDRLNIIH VTGTKGKGST CAFTECILRS YGLKTGFFSS PHLVQVRERI RINGQPISPE LFTKYFWRLY HRLEETKDGS CVSMPPYFRF LTLMAFHVFL QEKVDLAVVE VGIGGAYDCT NIIRKPVVCG VSSLGIDHTS LLGDTVEKIA WQKGGIFKQG VPAFTVLQPE GPLAVLRDRA QQISCPLYLC PMLEALEEGG PPLTLGLEGE HQRSNAALAL QLAHCWLQRQ DRHGAGEPKA SRPGLLWQLP LAPVFQPTSH MRLGLRNTEW PGRTQVLRRG PLTWYLDGAH TASSAQACVR WFRQALQGRE RPSGGPEVRV LLFNATGDRD PAALLKLLQP CQFDYAVFCP NLTEVSSTGN ADQQNFTVTL DQVLLRCLEH QQHWNHLDEE QASPDLWSAP SPEPGGSASL LLAPHPPHTC SASSLVFSCI SHALQWISQG RDPIFQPPSP PKGLLTHPVA HSGASILREA AAIHVLVTGS LHLVGGVLKL LEPALSQ
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