About Zona pellucida sperm-binding protein 2
Zona pellucida sperm-binding protein 2 (ZP2) is a protein
from Homo sapiens identified by UniProt accession
Q05996, 745 residues long.
MolForge cross-references it against 0 known binders and
51 disease associations.
Target properties
| Protein name | Zona pellucida sperm-binding protein 2 |
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| UniProt accession | Q05996 |
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| Gene | ZP2 |
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| Organism | Homo sapiens |
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| Length | 745 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (51)
Diseases linked to this target (Open Targets).
- female infertility due to zona pellucida defect · score 0.57
- cutaneous melanoma · score 0.25
- lung adenocarcinoma · score 0.25
- squamous cell lung carcinoma · score 0.18
- breast adenocarcinoma · score 0.16
- glioblastoma multiforme · score 0.15
- head and neck squamous cell carcinoma · score 0.13
- primary ovarian insufficiency · score 0.07
- colon carcinoma · score 0.06
- Female infertility due to fertilization defect · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q05996-F1 | alphafold | PREDICTED | 71.57 | — |
Amino-acid sequence (745 residues)
MACRQRGGSW SPSGWFNAGW STYRSISLFF ALVTSGNSID VSQLVNPAFP GTVTCDEREI TVEFPSSPGT KKWHASVVDP LGLDMPNCTY ILDPEKLTLR ATYDNCTRRV HGGHQMTIRV MNNSAALRHG AVMYQFFCPA MQVEETQGLS ASTICQKDFM SFSLPRVFSG LADDSKGTKV QMGWSIEVGD GARAKTLTLP EAMKEGFSLL IDNHRMTFHV PFNATGVTHY VQGNSHLYMV SLKLTFISPG QKVIFSSQAI CAPDPVTCNA THMTLTIPEF PGKLKSVSFE NQNIDVSQLH DNGIDLEATN GMKLHFSKTL LKTKLSEKCL LHQFYLASLK LTFLLRPETV SMVIYPECLC ESPVSIVTGE LCTQDGFMDV EVYSYQTQPA LDLGTLRVGN SSCQPVFEAQ SQGLVRFHIP LNGCGTRYKF EDDKVVYENE IHALWTDFPP SKISRDSEFR MTVKCSYSRN DMLLNINVES LTPPVASVKL GPFTLILQSY PDNSYQQPYG ENEYPLVRFL RQPIYMEVRV LNRDDPNIKL VLDDCWATST MDPDSFPQWN VVVDGCAYDL DNYQTTFHPV GSSVTHPDHY QRFDMKAFAF VSEAHVLSSL VYFHCSALIC NRLSPDSPLC SVTCPVSSRH RRATGATEAE KMTVSLPGPI LLLSDDSSFR GVGSSDLKAS GSSGEKSRSE TGEEVGSRGA MDTKGHKTAG DVGSKAVAAV AAFAGVVATL GFIYYLYEKR TVSNH
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