CTD small phosphatase-like protein 2 (CTDSPL2)

About CTD small phosphatase-like protein 2

CTD small phosphatase-like protein 2 (CTDSPL2) is a protein from Homo sapiens identified by UniProt accession Q05D32, 466 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.

Target properties

Protein name	CTD small phosphatase-like protein 2
UniProt accession	Q05D32
Gene	CTDSPL2
Organism	Homo sapiens
Length	466 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (26)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.48
mean corpuscular hemoglobin · score 0.39
high density lipoprotein cholesterol measurement · score 0.39
mean corpuscular hemoglobin concentration · score 0.39
triglyceride measurement · score 0.39
alcohol consumption measurement · score 0.37
alcohol drinking · score 0.37
mean corpuscular volume · score 0.36
eosinophil count · score 0.36
hemoglobin measurement · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q05D32-F1	alphafold	PREDICTED	65.62	—

Amino-acid sequence (466 residues)

MRLRTRKASQ QSNQIQTQRT ARAKRKYSEV DDSLPSGGEK PSKNETGLLS SIKKFIKGST PKEERENPSK RSRIERDIDN NLITSTPRAG EKPNKQISRV RRKSQVNGEA GSYEMTNQHV KQNGKLEDNP SSGSPPRTTL LGTIFSPVFN FFSPANKNGT SGSDSPGQAV EAEEIVKQLD MEQVDEITTS TTTSTNGAAY SNQAVQVRPS LNNGLEEAEE TVNRDIPPLT APVTPDSGYS SAHAEATYEE DWEVFDPYYF IKHVPPLTEE QLNRKPALPL KTRSTPEFSL VLDLDETLVH CSLNELEDAA LTFPVLFQDV IYQVYVRLRP FFREFLERMS QMYEIILFTA SKKVYADKLL NILDPKKQLV RHRLFREHCV CVQGNYIKDL NILGRDLSKT IIIDNSPQAF AYQLSNGIPI ESWFMDKNDN ELLKLIPFLE KLVELNEDVR PHIRDRFRLH DLLPPD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards