FHF complex subunit HOOK-interacting protein 1A…

About FHF complex subunit HOOK-interacting protein 1A

FHF complex subunit HOOK-interacting protein 1A (FHIP1A) is a protein from Homo sapiens identified by UniProt accession Q05DH4, 1040 residues long. MolForge cross-references it against 0 known binders and 94 disease associations.

Target properties

Protein name	FHF complex subunit HOOK-interacting protein 1A
UniProt accession	Q05DH4
Gene	FHIP1A
Organism	Homo sapiens
Length	1040 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (94)

Diseases linked to this target (Open Targets).

body height · score 0.42
platelet count · score 0.41
leukocyte count · score 0.37
appendicular lean mass · score 0.35
lean body mass · score 0.33
platelet crit · score 0.31
myeloid white cell count · score 0.30
neutrophil count · score 0.28
mathematical ability · score 0.26
cognitive function measurement · score 0.25

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q05DH4-F1	alphafold	PREDICTED	64.56	—

Amino-acid sequence (1040 residues)

MMSSVSTESK LQQAVSLQGV DPETCMIVFK NHWAQVVKIL EKHDPLKNTQ AKYGSIPPDE ASAVQNYVEH MLFLLIEEQA KDAAMGPILE FVVSENIMEK LFLWSLRREF TDETKIEQLK MYEMLVTQSH QPLLHHKPIL KPLMMLLSSC SGTTTPTVEE KLVVLLNQLC SILAKDPSIL ELFFHTSEDQ GAANFLIFSL LIPFIHREGS VGQQARDALL FIMSLSAENT MVAHHIVENT YFCPVLATGL SGLYSSLPTK LEEKGEEWHC LLKDDWLLLP SLVQFMNSLE FCNAVIQVAH PLIRNQLVNY IYNGFLVPVL APALHKVTVE EVMTTTAYLD LFLRSISEPA LLEIFLRFIL LHQHENVHIL DTLTSRINTP FRLCVVSLAL FRTLIGLHCE DVMLQLVLRY LIPCNHMMLS QRWAVKERDC YSVSAAKLLA LTPVCCSSGI TLTLGNQERD YILWSKCMHD TSGPVERPFP EAFSESACIV EYGKALDISY LQYLWEAHTN ILRCMRDCRV WSALYDGDSP DPEMFLQSLT EEGSVSSACP VFGLPQQLPR KTGPQLAPRK DKSQTELEWD DSYDTGISSG ADVGSPGPYD DLEVSGPPAP IDPPKHIQEM KKNALLLFKG SYIEESDFQD DVMVYRLCAE KDSEDMKDSQ EEAARPPAEA QAEVQSVPIN NGPLLSTQPE TDSEEEWNRD NSDPFHSEPK EPKQEREPEA APESNSELAS PAPEAEHSSN LTAAHPESEE LIAQYDQIIK ELDSGAEGLM EQNYPTPDPL LLTKEEEGKE ESKGEKEKEG KKELEDEEDD FDSFIAEMPA VETVPSPFVG RDEAAFASRH PVRTQSTPFT GPFISVVLSK LENMLENSLH VNLLLIGIIT QLASYPQPLL RSFLLNTNMV FQPSVRSLYQ VLASVKNKIE QFASVERDFP GLLIQAQQYL LFRVDMSDMT PAALTKDPIQ EASRTGSGKN LLDGPPRVLQ PFLTHRTKVA EAPPNLPLPV RNPMLAAALF PEFLKELAAL AQEHSILCYK ILGDFEDSCC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

FHF complex subunit HOOK-interacting protein 1A (FHIP1A)