Regenerating islet-derived protein 3-alpha (REG3A)

About Regenerating islet-derived protein 3-alpha

Regenerating islet-derived protein 3-alpha (REG3A) is a protein from Homo sapiens identified by UniProt accession Q06141, 175 residues long. MolForge cross-references it against 0 known binders and 218 disease associations.

Target properties

Protein name	Regenerating islet-derived protein 3-alpha
UniProt accession	Q06141
Gene	REG3A
Organism	Homo sapiens
Length	175 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (218)

Diseases linked to this target (Open Targets).

lung adenocarcinoma · score 0.19
squamous cell lung carcinoma · score 0.14
head and neck squamous cell carcinoma · score 0.12
MODY · score 0.11
breast adenocarcinoma · score 0.10
gonorrhea · score 0.10
neoplasm · score 0.10
type 2 diabetes mellitus · score 0.09
hepatocellular carcinoma · score 0.08
psoriasis · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q06141-F1	alphafold	PREDICTED	89.00	—

Amino-acid sequence (175 residues)

MLPPMALPSV SWMLLSCLML LSQVQGEEPQ RELPSARIRC PKGSKAYGSH CYALFLSPKS WTDADLACQK RPSGNLVSVL SGAEGSFVSS LVKSIGNSYS YVWIGLHDPT QGTEPNGEGW EWSSSDVMNY FAWERNPSTI SSPGHCASLS RSTAFLRWKD YNCNVRLPYV CKFTD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards