About Amidophosphoribosyltransferase
Amidophosphoribosyltransferase (PPAT) is a protein
from Homo sapiens identified by UniProt accession
Q06203, 517 residues long.
MolForge cross-references it against 0 known binders and
224 disease associations.
Target properties
| Protein name | Amidophosphoribosyltransferase |
|---|
| UniProt accession | Q06203 |
|---|
| Gene | PPAT |
|---|
| Organism | Homo sapiens |
|---|
| Length | 517 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (224)
Diseases linked to this target (Open Targets).
- acute lymphoblastic leukemia · score 0.60
- Crohn's disease · score 0.59
- rheumatoid arthritis · score 0.59
- adult acute lymphoblastic leukemia · score 0.58
- lymphoid leukemia · score 0.55
- ulcerative colitis · score 0.55
- microscopic polyangiitis · score 0.53
- lupus nephritis · score 0.50
- Churg-Strauss syndrome · score 0.49
- systemic lupus erythematosus · score 0.48
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q06203-F1 | alphafold | PREDICTED | 87.02 | — |
Amino-acid sequence (517 residues)
MELEELGIRE ECGVFGCIAS GEWPTQLDVP HVITLGLVGL QHRGQESAGI VTSDGSSVPT FKSHKGMGLV NHVFTEDNLK KLYVSNLGIG HTRYATTGKC ELENCQPFVV ETLHGKIAVA HNGELVNAAR LRKKLLRHGI GLSTSSDSEM ITQLLAYTPP QEQDDTPDWV ARIKNLMKEA PTAYSLLIMH RDVIYAVRDP YGNRPLCIGR LIPVSDINDK EKKTSETEGW VVSSESCSFL SIGARYYREV LPGEIVEISR HNVQTLDIIS RSEGNPVAFC IFEYVYFARP DSMFEDQMVY TVRYRCGQQL AIEAPVDADL VSTVPESATP AALAYAGKCG LPYVEVLCKN RYVGRTFIQP NMRLRQLGVA KKFGVLSDNF KGKRIVLVDD SIVRGNTISP IIKLLKESGA KEVHIRVASP PIKYPCFMGI NIPTKEELIA NKPEFDHLAE YLGANSVVYL SVEGLVSSVQ EGIKFKKQKE KKHDIMIQEN GNGLECFEKS GHCTACLTGK YPVELEW
Explore Amidophosphoribosyltransferase with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets