About Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (GFPT1) is a protein
from Homo sapiens identified by UniProt accession
Q06210, 699 residues long.
MolForge cross-references it against 0 known binders and
156 disease associations.
Target properties
| Protein name | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 |
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| UniProt accession | Q06210 |
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| Gene | GFPT1 |
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| Organism | Homo sapiens |
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| Length | 699 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (156)
Diseases linked to this target (Open Targets).
- Congenital myasthenic syndromes · score 0.80
- neurodegenerative disease · score 0.56
- congenital myasthenic syndrome · score 0.48
- congenital disorder of glycosylation type I · score 0.37
- congenital myasthenic syndromes with glycosylation defect · score 0.37
- lysosomal storage disease · score 0.37
- Abnormality of the musculature · score 0.34
- vertebral disorder · score 0.29
- calcium measurement · score 0.25
- spinal stenosis · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q06210-F1 | alphafold | PREDICTED | 92.88 | — |
Amino-acid sequence (699 residues)
MCGIFAYLNY HVPRTRREIL ETLIKGLQRL EYRGYDSAGV GFDGGNDKDW EANACKIQLI KKKGKVKALD EEVHKQQDMD LDIEFDVHLG IAHTRWATHG EPSPVNSHPQ RSDKNNEFIV IHNGIITNYK DLKKFLESKG YDFESETDTE TIAKLVKYMY DNRESQDTSF TTLVERVIQQ LEGAFALVFK SVHFPGQAVG TRRGSPLLIG VRSEHKLSTD HIPILYRTAR TQIGSKFTRW GSQGERGKDK KGSCNLSRVD STTCLFPVEE KAVEYYFASD ASAVIEHTNR VIFLEDDDVA AVVDGRLSIH RIKRTAGDHP GRAVQTLQME LQQIMKGNFS SFMQKEIFEQ PESVVNTMRG RVNFDDYTVN LGGLKDHIKE IQRCRRLILI ACGTSYHAGV ATRQVLEELT ELPVMVELAS DFLDRNTPVF RDDVCFFLSQ SGETADTLMG LRYCKERGAL TVGITNTVGS SISRETDCGV HINAGPEIGV ASTKAYTSQF VSLVMFALMM CDDRISMQER RKEIMLGLKR LPDLIKEVLS MDDEIQKLAT ELYHQKSVLI MGRGYHYATC LEGALKIKEI TYMHSEGILA GELKHGPLAL VDKLMPVIMI IMRDHTYAKC QNALQQVVAR QGRPVVICDK EDTETIKNTK RTIKVPHSVD CLQGILSVIP LQLLAFHLAV LRGYDVDFPR NLAKSVTVE
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