Exosome complex component RRP45 (EXOSC9)

About Exosome complex component RRP45

Exosome complex component RRP45 (EXOSC9) is a protein from Homo sapiens identified by UniProt accession Q06265, 439 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.

Target properties

Protein name	Exosome complex component RRP45
UniProt accession	Q06265
Gene	EXOSC9
Organism	Homo sapiens
Length	439 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (48)

Diseases linked to this target (Open Targets).

pontocerebellar hypoplasia type 1 · score 0.60
neurodegenerative disease · score 0.51
Cerebral atrophy · score 0.27
mean corpuscular volume · score 0.22
erythrocyte count · score 0.20
mean reticulocyte volume · score 0.19
genetic disorder · score 0.19
body height · score 0.19
lean body mass · score 0.19
HbA1c measurement · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q06265-F1	alphafold	PREDICTED	77.01	—

Amino-acid sequence (439 residues)

MKETPLSNCE RRFLLRAIEE KKRLDGRQTY DYRNIRISFG TDYGCCIVEL GKTRVLGQVS CELVSPKLNR ATEGILFFNL ELSQMAAPAF EPGRQSDLLV KLNRLMERCL RNSKCIDTES LCVVAGEKVW QIRVDLHLLN HDGNIIDAAS IAAIVALCHF RRPDVSVQGD EVTLYTPEER DPVPLSIHHM PICVSFAFFQ QGTYLLVDPN EREERVMDGL LVIAMNKHRE ICTIQSSGGI MLLKDQVLRC SKIAGVKVAE ITELILKALE NDQKVRKEGG KFGFAESIAN QRITAFKMEK APIDTSDVEE KAEEIIAEAE PPSEVVSTPV LWTPGTAQIG EGVENSWGDL EDSEKEDDEG GGDQAIILDG IKMDTGVEVS DIGSQDAPII LSDSEEEEMI ILEPDKNPKK IRTQTTSAKQ EKAPSKKPVK RRKKKRAAN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards