About Proteasome activator complex subunit 1
Proteasome activator complex subunit 1 (PSME1) is a protein
from Homo sapiens identified by UniProt accession
Q06323, 249 residues long.
MolForge cross-references it against 0 known binders and
92 disease associations.
Target properties
| Protein name | Proteasome activator complex subunit 1 |
|---|
| UniProt accession | Q06323 |
|---|
| Gene | PSME1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 249 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (92)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.46
- neurodegenerative disease · score 0.46
- ovarian cancer · score 0.29
- endometrial cancer · score 0.29
- lung adenocarcinoma · score 0.28
- urinary bladder cancer · score 0.28
- head and neck squamous cell carcinoma · score 0.28
- gastric adenocarcinoma · score 0.27
- body height · score 0.09
- oral squamous cell carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q06323-F1 | alphafold | PREDICTED | 90.75 | — |
Amino-acid sequence (249 residues)
MAMLRVQPEA QAKVDVFRED LCTKTENLLG SYFPKKISEL DAFLKEPALN EANLSNLKAP LDIPVPDPVK EKEKEERKKQ QEKEDKDEKK KGEDEDKGPP CGPVNCNEKI VVLLQRLKPE IKDVIEQLNL VTTWLQLQIP RIEDGNNFGV AVQEKVFELM TSLHTKLEGF HTQISKYFSE RGDAVTKAAK QPHVGDYRQL VHELDEAEYR DIRLMVMEIR NAYAVLYDII LKNFEKLKKP RGETKGMIY
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