Myocyte-specific enhancer factor 2C (MEF2C)

About Myocyte-specific enhancer factor 2C

Myocyte-specific enhancer factor 2C (MEF2C) is a protein from Homo sapiens identified by UniProt accession Q06413, 473 residues long. MolForge cross-references it against 0 known binders and 436 disease associations.

Target properties

Protein name	Myocyte-specific enhancer factor 2C
UniProt accession	Q06413
Gene	MEF2C
Organism	Homo sapiens
Length	473 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (436)

Diseases linked to this target (Open Targets).

5q14.3 microdeletion syndrome · score 0.57
autism spectrum disorder · score 0.56
genetic disorder · score 0.53
mean corpuscular volume · score 0.52
platelet count · score 0.52
erythrocyte count · score 0.52
self reported educational attainment · score 0.51
mean platelet volume · score 0.51
mean corpuscular hemoglobin · score 0.50
mean corpuscular hemoglobin concentration · score 0.49

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q06413-F1	alphafold	PREDICTED	55.65	—

Amino-acid sequence (473 residues)

MGRKKIQITR IMDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS TNKLFQYAST DMDKVLLKYT EYNEPHESRT NSDIVETLRK KGLNGCDSPD PDADDSVGHS PESEDKYRKI NEDIDLMISR QRLCAVPPPN FEMPVSIPVS SHNSLVYSNP VSSLGNPNLL PLAHPSLQRN SMSPGVTHRP PSAGNTGGLM GGDLTSGAGT SAGNGYGNPR NSPGLLVSPG NLNKNMQAKS PPPMNLGMNN RKPDLRVLIP PGSKNTMPSV SEDVDLLLNQ RINNSQSAQS LATPVVSVAT PTLPGQGMGG YPSAISTTYG TEYSLSSADL SSLSGFNTAS ALHLGSVTGW QQQHLHNMPP SALSQLGACT STHLSQSSNL SLPSTQSLNI KSEPVSPPRD RTTTPSRYPQ HTRHEAGRSP VDSLSSCSSS YDGSDREDHR NEFHSPIGLT RPSPDERESP SVKRMRLSEG WAT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards