POU domain, class 5, transcription factor 1B (POU5F1B)

About POU domain, class 5, transcription factor 1B

POU domain, class 5, transcription factor 1B (POU5F1B) is a protein from Homo sapiens identified by UniProt accession Q06416, 359 residues long. MolForge cross-references it against 0 known binders and 81 disease associations.

Target properties

Protein name	POU domain, class 5, transcription factor 1B
UniProt accession	Q06416
Gene	POU5F1B
Organism	Homo sapiens
Length	359 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (81)

Diseases linked to this target (Open Targets).

prostate carcinoma · score 0.51
colorectal cancer · score 0.49
breast carcinoma · score 0.45
cancer · score 0.42
BMI-adjusted waist-hip ratio · score 0.40
digestive system cancer · score 0.38
waist-hip ratio · score 0.38
colorectal adenoma · score 0.38
benign colon neoplasm · score 0.37
BMI-adjusted waist circumference · score 0.36

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q06416-F1	alphafold	PREDICTED	64.37	—

Amino-acid sequence (359 residues)

MAGHLASDFA FSPPPGGGGD GPWGAEPGWV DPLTWLSFQG PPGGPGIGPG VGPGSEVWGI PPCPPPYELC GGMAYCGPQV GVGLVPQGGL ETSQPESEAG VGVESNSNGA SPEPCTVPPG AVKLEKEKLE QNPEKSQDIK ALQKELEQFA KLLKQKRITL GYTQADVGLI LGVLFGKVFS QKTICRFEAL QLSFKNMCKL RPLLQKWVEE ADNNENLQEI CKAETLMQAR KRKRTSIENR VRGNLENLFL QCPKPTLQIS HIAQQLGLEK DVVRVWFCNR RQKGKRSSSD YAQREDFEAA GSPFSGGPVS FPPAPGPHFG TPGYGSPHFT ALYSSVPFPE GEVFPPVSVI TLGSPMHSN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards