About Protein CBFA2T1
Protein CBFA2T1 (RUNX1T1) is a protein
from Homo sapiens identified by UniProt accession
Q06455, 604 residues long.
MolForge cross-references it against 0 known binders and
320 disease associations.
Target properties
| Protein name | Protein CBFA2T1 |
|---|
| UniProt accession | Q06455 |
|---|
| Gene | RUNX1T1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 604 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (320)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- smoking status measurement · score 0.44
- mathematical ability · score 0.40
- acute myeloid leukemia · score 0.40
- risk-taking behaviour · score 0.40
- attention deficit hyperactivity disorder · score 0.39
- alcohol consumption measurement · score 0.39
- antisocial behaviour measurement · score 0.39
- substance abuse · score 0.39
- smoking initiation · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q06455-F1 | alphafold | PREDICTED | 63.41 | — |
Amino-acid sequence (604 residues)
MISVKRNTWR ALSLVIGDCR KKGNFEYCQD RTEKHSTMPD SPVDVKTQSR LTPPTMPPPP TTQGAPRTSS FTPTTLTNGT SHSPTALNGA PSPPNGFSNG PSSSSSSSLA NQQLPPACGA RQLSKLKRFL TTLQQFGNDI SPEIGERVRT LVLGLVNSTL TIEEFHSKLQ EATNFPLRPF VIPFLKANLP LLQRELLHCA RLAKQNPAQY LAQHEQLLLD ASTTSPVDSS ELLLDVNENG KRRTPDRTKE NGFDREPLHS EHPSKRPCTI SPGQRYSPNN GLSYQPNGLP HPTPPPPQHY RLDDMAIAHH YRDSYRHPSH RDLRDRNRPM GLHGTRQEEM IDHRLTDREW AEEWKHLDHL LNCIMDMVEK TRRSLTVLRR CQEADREELN YWIRRYSDAE DLKKGGGSSS SHSRQQSPVN PDPVALDAHR EFLHRPASGY VPEEIWKKAE EAVNEVKRQA MTELQKAVSE AERKAHDMIT TERAKMERTV AEAKRQAAED ALAVINQQED SSESCWNCGR KASETCSGCN TARYCGSFCQ HKDWEKHHHI CGQTLQAQQQ GDTPAVSSSV TPNSGAGSPM DTPPAATPRS TTPGTPSTIE TTPR
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