About Amyloid beta precursor like protein 2
Amyloid beta precursor like protein 2 (APLP2) is a protein
from Homo sapiens identified by UniProt accession
Q06481, 763 residues long.
MolForge cross-references it against 0 known binders and
154 disease associations.
Target properties
| Protein name | Amyloid beta precursor like protein 2 |
|---|
| UniProt accession | Q06481 |
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| Gene | APLP2 |
|---|
| Organism | Homo sapiens |
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| Length | 763 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (154)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.40
- breast adenocarcinoma · score 0.25
- pancreatic adenocarcinoma · score 0.15
- glioblastoma multiforme · score 0.14
- esophageal cancer · score 0.12
- neoplasm · score 0.10
- pancreatic neoplasm · score 0.09
- Myopia · score 0.08
- myopia · score 0.08
- mild neurocognitive disorder · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q06481-F1 | alphafold | PREDICTED | 68.35 | — |
Amino-acid sequence (763 residues)
MAATGTAAAA ATGRLLLLLL VGLTAPALAL AGYIEALAAN AGTGFAVAEP QIAMFCGKLN MHVNIQTGKW EPDPTGTKSC FETKEEVLQY CQEMYPELQI TNVMEANQRV SIDNWCRRDK KQCKSRFVTP FKCLVGEFVS DVLLVPEKCQ FFHKERMEVC ENHQHWHTVV KEACLTQGMT LYSYGMLLPC GVDQFHGTEY VCCPQTKIIG SVSKEEEEED EEEEEEEDEE EDYDVYKSEF PTEADLEDFT EAAVDEDDED EEEGEEVVED RDYYYDTFKG DDYNEENPTE PGSDGTMSDK EITHDVKAVC SQEAMTGPCR AVMPRWYFDL SKGKCVRFIY GGCGGNRNNF ESEDYCMAVC KAMIPPTPLP TNDVDVYFET SADDNEHARF QKAKEQLEIR HRNRMDRVKK EWEEAELQAK NLPKAERQTL IQHFQAMVKA LEKEAASEKQ QLVETHLARV EAMLNDRRRM ALENYLAALQ SDPPRPHRIL QALRRYVRAE NKDRLHTIRH YQHVLAVDPE KAAQMKSQVM THLHVIEERR NQSLSLLYKV PYVAQEIQEE IDELLQEQRA DMDQFTASIS ETPVDVRVSS EESEEIPPFH PFHPFPALPE NEDTQPELYH PMKKGSGVGE QDGGLIGAEE KVINSKNKVD ENMVIDETLD VKEMIFNAER VGGLEEERES VGPLREDFSL SSSALIGLLV IAVAIATVIV ISLVMLRKRQ YGTISHGIVE VDPMLTPEER HLNKMQNHGY ENPTYKYLEQ MQI
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