About Sodium-dependent phosphate transport protein 2A
Sodium-dependent phosphate transport protein 2A (SLC34A1) is a protein
from Homo sapiens identified by UniProt accession
Q06495, 639 residues long.
MolForge cross-references it against 0 known binders and
164 disease associations.
Target properties
| Protein name | Sodium-dependent phosphate transport protein 2A |
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| UniProt accession | Q06495 |
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| Gene | SLC34A1 |
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| Organism | Homo sapiens |
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| Length | 639 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (164)
Diseases linked to this target (Open Targets).
- hypercalcemia, infantile, 2 · score 0.75
- hypophosphatemic nephrolithiasis/osteoporosis 1 · score 0.72
- Autosomal recessive infantile hypercalcemia · score 0.69
- Fanconi renotubular syndrome 2 · score 0.57
- creatinine measurement · score 0.54
- cystatin C measurement · score 0.50
- nephrolithiasis · score 0.47
- nephrocalcinosis · score 0.38
- Fanconi renotubular syndrome 1 · score 0.38
- hereditary hypophosphatemic rickets with hypercalciuria · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q06495-F1 | alphafold | PREDICTED | 72.06 | — |
Amino-acid sequence (639 residues)
MLSYGERLGS PAVSPLPVRG GHVMRGTAFA YVPSPQVLHR IPGTSAYAFP SLGPVALAEH TCPCGEVLER HEPLPAKLAL EEEQKPESRL VPKLRQAGAM LLKVPLMLTF LYLFVCSLDM LSSAFQLAGG KVAGDIFKDN AILSNPVAGL VVGILVTVLV QSSSTSTSII VSMVSSGLLE VSSAIPIIMG SNIGTSVTNT IVALMQAGDR TDFRRAFAGA TVHDCFNWLS VLVLLPLEAA TGYLHHITRL VVASFNIHGG RDAPDLLKII TEPFTKLIIQ LDESVITSIA TGDESLRNHS LIQIWCHPDS LQAPTSMSRA EANSSQTLGN ATMEKCNHIF VDTGLPDLAV GLILLAGSLV LLCTCLILLV KMLNSLLKGQ VAKVIQKVIN TDFPAPFTWV TGYFAMVVGA SMTFVVQSSS VFTSAITPLI GLGVISIERA YPLTLGSNIG TTTTAILAAL ASPREKLSSA FQIALCHFFF NISGILLWYP VPCTRLPIRM AKALGKRTAK YRWFAVLYLL VCFLLLPSLV FGISMAGWQV MVGVGTPFGA LLAFVVLINV LQSRSPGHLP KWLQTWDFLP RWMHSLKPLD HLITRATLCC ARPEPRSPPL PPRVFLEELP PATPSPRLAL PAHHNATRL
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