GA-binding protein alpha chain (GABPA)

About GA-binding protein alpha chain

GA-binding protein alpha chain (GABPA) is a protein from Homo sapiens identified by UniProt accession Q06546, 454 residues long. MolForge cross-references it against 0 known binders and 159 disease associations.

Target properties

Protein name	GA-binding protein alpha chain
UniProt accession	Q06546
Gene	GABPA
Organism	Homo sapiens
Length	454 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (159)

Diseases linked to this target (Open Targets).

neoplasm · score 0.10
breast cancer · score 0.08
hepatocellular carcinoma · score 0.08
nonpapillary renal cell carcinoma · score 0.07
Syndactyly type 2 · score 0.07
erythrocyte count · score 0.07
Crigler-Najjar syndrome type 2 · score 0.06
pachyonychia congenita · score 0.06
syndactyly type 4 · score 0.06
schizophrenia · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q06546-F1	alphafold	PREDICTED	67.72	—

Amino-acid sequence (454 residues)

MTKREAEELI EIEIDGTEKA ECTEESIVEQ TYAPAECVSQ AIDINEPIGN LKKLLEPRLQ CSLDAHEICL QDIQLDPERS LFDQGVKTDG TVQLSVQVIS YQGIEPKLNI LEIVKPADTV EVVIDPDAHH AESEAHLVEE AQVITLDGTK HITTISDETS EQVTRWAAAL EGYRKEQERL GIPYDPIQWS TDQVLHWVVW VMKEFSMTDI DLTTLNISGR ELCSLNQEDF FQRVPRGEIL WSHLELLRKY VLASQEQQMN EIVTIDQPVQ IIPASVQSAT PTTIKVINSS AKAAKVQRAP RISGEDRSSP GNRTGNNGQI QLWQFLLELL TDKDARDCIS WVGDEGEFKL NQPELVAQKW GQRKNKPTMN YEKLSRALRY YYDGDMICKV QGKRFVYKFV CDLKTLIGYS AAELNRLVTE CEQKKLAKMQ LHGIAQPVTA VALATASLQT EKDN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards