GA-binding protein subunit beta-1 (GABPB1)

About GA-binding protein subunit beta-1

GA-binding protein subunit beta-1 (GABPB1) is a protein from Homo sapiens identified by UniProt accession Q06547, 395 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.

Target properties

Protein name	GA-binding protein subunit beta-1
UniProt accession	Q06547
Gene	GABPB1
Organism	Homo sapiens
Length	395 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (36)

Diseases linked to this target (Open Targets).

platelet count · score 0.28
platelet crit · score 0.24
testosterone measurement · score 0.23
adolescent idiopathic scoliosis · score 0.13
spastic paraplegia-glaucoma-intellectual disability syndrome · score 0.06
hereditary spastic paraplegia 34 · score 0.06
X-linked spastic paraplegia type 34 · score 0.06
Autosomal recessive spastic paraplegia type 24 · score 0.05
hereditary spastic paraplegia 24 · score 0.05
Spastic paraplegia - glaucoma - intellectual disability · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q06547-F1	alphafold	PREDICTED	68.10	—

Amino-acid sequence (395 residues)

MSLVDLGKKL LEAARAGQDD EVRILMANGA PFTTDWLGTS PLHLAAQYGH YSTTEVLLRA GVSRDARTKV DRTPLHMAAS EGHASIVEVL LKHGADVNAK DMLKMTALHW ATEHNHQEVV ELLIKYGADV HTQSKFCKTA FDISIDNGNE DLAEILQIAM QNQINTNPES PDTVTIHAAT PQFIIGPGGV VNLTGLVSSE NSSKATDETG VSAVQFGNSS TSVLATLAAL AEASAPLSNS SETPVVATEE VVTAESVDGA IQQVVSSGGQ QVITIVTDGI QLGNLHSIPT SGIGQPIIVT MPDGQQVLTV PATDIAEETV ISEEPPAKRQ CIEIIENRVE SAEIEEREAL QKQLDEANRE AQKYRQQLLK KEQEAEAYRQ KLEAMTRLQT NKEAV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards