E3 ubiquitin-protein ligase RING1 (RING1)

About E3 ubiquitin-protein ligase RING1

E3 ubiquitin-protein ligase RING1 (RING1) is a protein from Homo sapiens identified by UniProt accession Q06587, 406 residues long. MolForge cross-references it against 0 known binders and 113 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase RING1
UniProt accession	Q06587
Gene	RING1
Organism	Homo sapiens
Length	406 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (113)

Diseases linked to this target (Open Targets).

ovarian cancer · score 0.26
endometrial cancer · score 0.25
esophageal cancer · score 0.20
head and neck squamous cell carcinoma · score 0.18
gastric adenocarcinoma · score 0.12
asthma · score 0.11
autosomal recessive spondylocostal dysostosis · score 0.09
colitis · score 0.07
Scheuermann disease · score 0.07
brachyolmia, Maroteaux type · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q06587-F1	alphafold	PREDICTED	70.00	—

Amino-acid sequence (406 residues)

MTTPANAQNA SKTWELSLYE LHRTPQEAIM DGTEIAVSPR SLHSELMCPI CLDMLKNTMT TKECLHRFCS DCIVTALRSG NKECPTCRKK LVSKRSLRPD PNFDALISKI YPSREEYEAH QDRVLIRLSR LHNQQALSSS IEEGLRMQAM HRAQRVRRPI PGSDQTTTMS GGEGEPGEGE GDGEDVSSDS APDSAPGPAP KRPRGGGAGG SSVGTGGGGT GGVGGGAGSE DSGDRGGTLG GGTLGPPSPP GAPSPPEPGG EIELVFRPHP LLVEKGEYCQ TRYVKTTGNA TVDHLSKYLA LRIALERRQQ QEAGEPGGPG GGASDTGGPD GCGGEGGGAG GGDGPEEPAL PSLEGVSEKQ YTIYIAPGGG AFTTLNGSLT LELVNEKFWK VSRPLELCYA PTKDPK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards