Paired box protein Pax-8 (PAX8)

About Paired box protein Pax-8

Paired box protein Pax-8 (PAX8) is a protein from Homo sapiens identified by UniProt accession Q06710, 450 residues long. MolForge cross-references it against 0 known binders and 629 disease associations.

Target properties

Protein name	Paired box protein Pax-8
UniProt accession	Q06710
Gene	PAX8
Organism	Homo sapiens
Length	450 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (629)

Diseases linked to this target (Open Targets).

congenital hypothyroidism · score 0.66
neurodegenerative disease · score 0.50
thyroid hypoplasia · score 0.46
sleep duration · score 0.44
urate measurement · score 0.44
blood urea nitrogen measurement · score 0.44
calcium measurement · score 0.42
body mass index · score 0.41
insomnia measurement · score 0.41
functional brain measurement · score 0.40

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q06710-F1	alphafold	PREDICTED	57.71	—

Amino-acid sequence (450 residues)

MPHNSIRSGH GGLNQLGGAF VNGRPLPEVV RQRIVDLAHQ GVRPCDISRQ LRVSHGCVSK ILGRYYETGS IRPGVIGGSK PKVATPKVVE KIGDYKRQNP TMFAWEIRDR LLAEGVCDND TVPSVSSINR IIRTKVQQPF NLPMDSCVAT KSLSPGHTLI PSSAVTPPES PQSDSLGSTY SINGLLGIAQ PGSDKRKMDD SDQDSCRLSI DSQSSSSGPR KHLRTDAFSQ HHLEPLECPF ERQHYPEAYA SPSHTKGEQG LYPLPLLNST LDDGKATLTP SNTPLGRNLS THQTYPVVAD PHSPFAIKQE TPEVSSSSST PSSLSSSAFL DLQQVGSGVP PFNAFPHAAS VYGQFTGQAL LSGREMVGPT LPGYPPHIPT SGQGSYASSA IAGMVAGSEY SGNAYGHTPY SSYSEAWRFP NSSLLSSPYY YSSTSRPSAP PTTATAFDHL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards