About Fragile X messenger ribonucleoprotein 1
Fragile X messenger ribonucleoprotein 1 (FMR1) is a protein
from Homo sapiens identified by UniProt accession
Q06787, 632 residues long.
MolForge cross-references it against 0 known binders and
521 disease associations.
Target properties
| Protein name | Fragile X messenger ribonucleoprotein 1 |
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| UniProt accession | Q06787 |
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| Gene | FMR1 |
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| Organism | Homo sapiens |
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| Length | 632 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (521)
Diseases linked to this target (Open Targets).
- fragile X syndrome · score 0.80
- fragile X-associated tremor/ataxia syndrome · score 0.70
- premature ovarian failure 1 · score 0.65
- primary ovarian insufficiency · score 0.51
- Intellectual disability · score 0.50
- genetic disorder · score 0.45
- Autistic behavior · score 0.27
- Neurodevelopmental abnormality · score 0.11
- neoplasm · score 0.10
- attention deficit hyperactivity disorder · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q06787-F1 | alphafold | PREDICTED | 69.35 | — |
Amino-acid sequence (632 residues)
MEELVVEVRG SNGAFYKAFV KDVHEDSITV AFENNWQPDR QIPFHDVRFP PPVGYNKDIN ESDEVEVYSR ANEKEPCCWW LAKVRMIKGE FYVIEYAACD ATYNEIVTIE RLRSVNPNKP ATKDTFHKIK LDVPEDLRQM CAKEAAHKDF KKAVGAFSVT YDPENYQLVI LSINEVTSKR AHMLIDMHFR SLRTKLSLIM RNEEASKQLE SSRQLASRFH EQFIVREDLM GLAIGTHGAN IQQARKVPGV TAIDLDEDTC TFHIYGEDQD AVKKARSFLE FAEDVIQVPR NLVGKVIGKN GKLIQEIVDK SGVVRVRIEA ENEKNVPQEE EIMPPNSLPS NNSRVGPNAP EEKKHLDIKE NSTHFSQPNS TKVQRVLVAS SVVAGESQKP ELKAWQGMVP FVFVGTKDSI ANATVLLDYH LNYLKEVDQL RLERLQIDEQ LRQIGASSRP PPNRTDKEKS YVTDDGQGMG RGSRPYRNRG HGRRGPGYTS GTNSEASNAS ETESDHRDEL SDWSLAPTEE ERESFLRRGD GRRRGGGGRG QGGRGRGGGF KGNDDHSRTD NRPRNPREAK GRTTDGSLQI RVDCNNERSV HTKTLQNTSS EGSRLRTGKD RNQKKEKPDS VDGQQPLVNG VP
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