Early growth response protein 3 (EGR3)

About Early growth response protein 3

Early growth response protein 3 (EGR3) is a protein from Homo sapiens identified by UniProt accession Q06889, 387 residues long. MolForge cross-references it against 0 known binders and 228 disease associations.

Target properties

Protein name	Early growth response protein 3
UniProt accession	Q06889
Gene	EGR3
Organism	Homo sapiens
Length	387 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (228)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.33
mathematical ability · score 0.25
self reported educational attainment · score 0.24
body height · score 0.22
Neurodevelopmental delay · score 0.12
schizophrenia · score 0.10
Abnormal central motor function · score 0.10
neoplasm · score 0.10
PHF-tau measurement · score 0.09
hair color · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q06889-F1	alphafold	PREDICTED	49.97	—

Amino-acid sequence (387 residues)

MTGKLAEKLP VTMSSLLNQL PDNLYPEEIP SALNLFSGSS DSVVHYNQMA TENVMDIGLT NEKPNPELSY SGSFQPAPGN KTVTYLGKFA FDSPSNWCQD NIISLMSAGI LGVPPASGAL STQTSTASMV QPPQGDVEAM YPALPPYSNC GDLYSEPVSF HDPQGNPGLA YSPQDYQSAK PALDSNLFPM IPDYNLYHHP NDMGSIPEHK PFQGMDPIRV NPPPITPLET IKAFKDKQIH PGFGSLPQPP LTLKPIRPRK YPNRPSKTPL HERPHACPAE GCDRRFSRSD ELTRHLRIHT GHKPFQCRIC MRSFSRSDHL TTHIRTHTGE KPFACEFCGR KFARSDERKR HAKIHLKQKE KKAEKGGAPS ASSAPPVSLA PVVTTCA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards