About Cyclin-dependent kinase 18
Cyclin-dependent kinase 18 (CDK18) is a protein
from Homo sapiens identified by UniProt accession
Q07002, 474 residues long.
MolForge cross-references it against 0 known binders and
52 disease associations.
Target properties
| Protein name | Cyclin-dependent kinase 18 |
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| UniProt accession | Q07002 |
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| Gene | CDK18 |
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| Organism | Homo sapiens |
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| Length | 474 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (52)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- serum gamma-glutamyl transferase measurement · score 0.32
- urate measurement · score 0.28
- blood phosphate measurement · score 0.28
- bowel opening frequency · score 0.26
- serum alanine aminotransferase measurement · score 0.21
- sleep measurement · score 0.13
- neoplasm · score 0.11
- small cell lung carcinoma · score 0.08
- chronic lymphocytic leukemia · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q07002-F1 | alphafold | PREDICTED | 73.18 | — |
Amino-acid sequence (474 residues)
MIMNKMKNFK RRFSLSVPRT ETIEESLAEF TEQFNQLHNR RNENLQLGPL GRDPPQECST FSPTDSGEEP GQLSPGVQFQ RRQNQRRFSM EDVSKRLSLP MDIRLPQEFL QKLQMESPDL PKPLSRMSRR ASLSDIGFGK LETYVKLDKL GEGTYATVFK GRSKLTENLV ALKEIRLEHE EGAPCTAIRE VSLLKNLKHA NIVTLHDLIH TDRSLTLVFE YLDSDLKQYL DHCGNLMSMH NVKIFMFQLL RGLAYCHHRK ILHRDLKPQN LLINERGELK LADFGLARAK SVPTKTYSNE VVTLWYRPPD VLLGSTEYST PIDMWGVGCI HYEMATGRPL FPGSTVKEEL HLIFRLLGTP TEETWPGVTA FSEFRTYSFP CYLPQPLINH APRLDTDGIH LLSSLLLYES KSRMSAEAAL SHSYFRSLGE RVHQLEDTAS IFSLKEIQLQ KDPGYRGLAF QQPGRGKNRR QSIF
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