About Large ribosomal subunit protein eL18
Large ribosomal subunit protein eL18 (RPL18) is a protein
from Homo sapiens identified by UniProt accession
Q07020, 188 residues long.
MolForge cross-references it against 0 known binders and
53 disease associations.
Target properties
| Protein name | Large ribosomal subunit protein eL18 |
|---|
| UniProt accession | Q07020 |
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| Gene | RPL18 |
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| Organism | Homo sapiens |
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| Length | 188 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (53)
Diseases linked to this target (Open Targets).
- Duchenne muscular dystrophy · score 0.50
- cystic fibrosis · score 0.50
- influenza · score 0.46
- Blackfan-Diamond anemia · score 0.45
- Diamond-Blackfan anemia · score 0.38
- Becker muscular dystrophy · score 0.29
- clear cell renal carcinoma · score 0.27
- endometrial cancer · score 0.27
- qualitative or quantitative defects of dystrophin · score 0.26
- aniridia · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q07020-F1 | alphafold | PREDICTED | 95.49 | — |
Amino-acid sequence (188 residues)
MGVDIRHNKD RKVRRKEPKS QDIYLRLLVK LYRFLARRTN STFNQVVLKR LFMSRTNRPP LSLSRMIRKM KLPGRENKTA VVVGTITDDV RVQEVPKLKV CALRVTSRAR SRILRAGGKI LTFDQLALDS PKGCGTVLLS GPRKGREVYR HFGKAPGTPH SHTKPYVRSK GRKFERARGR RASRGYKN
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