NKG2-E type II integral membrane protein (KLRC3)

About NKG2-E type II integral membrane protein

NKG2-E type II integral membrane protein (KLRC3) is a protein from Homo sapiens identified by UniProt accession Q07444, 240 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.

Target properties

Protein name	NKG2-E type II integral membrane protein
UniProt accession	Q07444
Gene	KLRC3
Organism	Homo sapiens
Length	240 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (50)

Diseases linked to this target (Open Targets).

neutrophil percentage of leukocytes · score 0.18
monocyte count · score 0.15
granulocyte percentage of myeloid white cells · score 0.13
platelet crit · score 0.12
aspartate aminotransferase measurement · score 0.11
platelet count · score 0.10
monocyte percentage of leukocytes · score 0.09
serum alanine aminotransferase measurement · score 0.08
reticulocyte count · score 0.08
glioblastoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q07444-F1	alphafold	PREDICTED	70.99	—

Amino-acid sequence (240 residues)

MSKQRGTFSE VSLAQDPKWQ QRKPKGNKSS ISGTEQEIFQ VELNLQNASL NHQGIDKIYD CQGLLPPPEK LTAEVLGIIC IVLMATVLKT IVLIPFLEQN NSSPNARTQK ARHCGHCPEE WITYSNSCYY IGKERRTWEE SLQACASKNS SSLLCIDNEE EMKFLASILP SSWIGVFRNS SHHPWVTING LAFKHEIKDS DHAERNCAML HVRGLISDQC GSSRIIRRGF IMLTRLVLNS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards