About Keratin-associated protein 1-1
Keratin-associated protein 1-1 (KRTAP1-1) is a protein
from Homo sapiens identified by UniProt accession
Q07627, 177 residues long.
MolForge cross-references it against 0 known binders and
25 disease associations.
Target properties
| Protein name | Keratin-associated protein 1-1 |
|---|
| UniProt accession | Q07627 |
|---|
| Gene | KRTAP1-1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 177 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (25)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.23
- clear cell renal carcinoma · score 0.18
- head and neck squamous cell carcinoma · score 0.18
- glioblastoma multiforme · score 0.18
- breast adenocarcinoma · score 0.18
- thyroid gland adenocarcinoma · score 0.16
- low grade glioma · score 0.11
- sebaceous of Jadassohn nevus · score 0.05
- thrombotic disease · score 0.01
- neoplasm · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q07627-F1 | alphafold | PREDICTED | 39.21 | — |
Amino-acid sequence (177 residues)
MACCQTSFCG FPSCSTSGTC GSSCCQPSCC ETSSCQPRCC ETSCCQPSCC QTSFCGFPSF STGGTCDSSC CQPSCCETSC CQPSCYQTSS CGTGCGIGGG IGYGQEGSSG AVSTRIRWCR PDCRVEGTCL PPCCVVSCTP PSCCQLHHAE ASCCRPSYCG QSCCRPVCCC YCSEPTC
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