Trefoil factor 3 (TFF3)

About Trefoil factor 3

Trefoil factor 3 (TFF3) is a protein from Homo sapiens identified by UniProt accession Q07654, 80 residues long. MolForge cross-references it against 0 known binders and 374 disease associations.

Target properties

Protein name	Trefoil factor 3
UniProt accession	Q07654
Gene	TFF3
Organism	Homo sapiens
Length	80 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (374)

Diseases linked to this target (Open Targets).

lean body mass · score 0.35
fat body mass · score 0.28
bone measurement · score 0.28
high density lipoprotein cholesterol measurement · score 0.15
inflammatory bowel disease · score 0.15
thyroid disease · score 0.13
neoplasm · score 0.11
hepatocellular carcinoma · score 0.10
neuritic plaque measurement · score 0.09
breast carcinoma · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q07654-F1	alphafold	PREDICTED	81.43	—

Amino-acid sequence (80 residues)

MAARALCMLG LVLALLSSSS AEEYVGLSAN QCAVPAKDRV DCGYPHVTPK ECNNRGCCFD SRIPGVPWCF KPLQEAECTF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards