About KH domain-containing, RNA-binding, signal transduction-associated protein 1
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1) is a protein
from Homo sapiens identified by UniProt accession
Q07666, 443 residues long.
MolForge cross-references it against 0 known binders and
142 disease associations.
Target properties
| Protein name | KH domain-containing, RNA-binding, signal transduction-associated protein 1 |
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| UniProt accession | Q07666 |
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| Gene | KHDRBS1 |
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| Organism | Homo sapiens |
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| Length | 443 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (142)
Diseases linked to this target (Open Targets).
- primary ovarian insufficiency · score 0.31
- lung adenocarcinoma · score 0.19
- endometrial cancer · score 0.18
- premature menopause · score 0.18
- Premature ovarian insufficiency · score 0.18
- breast adenocarcinoma · score 0.15
- gastric adenocarcinoma · score 0.12
- head and neck squamous cell carcinoma · score 0.12
- neoplasm · score 0.11
- cancer · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q07666-F1 | alphafold | PREDICTED | 64.86 | — |
Amino-acid sequence (443 residues)
MQRRDDPAAR MSRSSGRSGS MDPSGAHPSV RQTPSRQPPL PHRSRGGGGG SRGGARASPA TQPPPLLPPS ATGPDATVGG PAPTPLLPPS ATASVKMEPE NKYLPELMAE KDSLDPSFTH AMQLLTAEIE KIQKGDSKKD DEENYLDLFS HKNMKLKERV LIPVKQYPKF NFVGKILGPQ GNTIKRLQEE TGAKISVLGK GSMRDKAKEE ELRKGGDPKY AHLNMDLHVF IEVFGPPCEA YALMAHAMEE VKKFLVPDMM DDICQEQFLE LSYLNGVPEP SRGRGVPVRG RGAAPPPPPV PRGRGVGPPR GALVRGTPVR GAITRGATVT RGVPPPPTVR GAPAPRARTA GIQRIPLPPP PAPETYEEYG YDDTYAEQSY EGYEGYYSQS QGDSEYYDYG HGEVQDSYEA YGQDDWNGTR PSLKAPPARP VKGAYREHPY GRY
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