About Apoptosis regulator BAX
Apoptosis regulator BAX (BAX) is a protein
from Homo sapiens identified by UniProt accession
Q07812, 192 residues long.
MolForge cross-references it against 0 known binders and
1,238 disease associations.
Target properties
| Protein name | Apoptosis regulator BAX |
|---|
| UniProt accession | Q07812 |
|---|
| Gene | BAX |
|---|
| Organism | Homo sapiens |
|---|
| Length | 192 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (1238)
Diseases linked to this target (Open Targets).
- T-cell acute lymphoblastic leukemia · score 0.46
- colon carcinoma · score 0.43
- endometrial carcinoma · score 0.38
- neurodegenerative disease · score 0.38
- colon adenocarcinoma · score 0.37
- gastric adenocarcinoma · score 0.37
- colorectal adenocarcinoma · score 0.37
- endometrium adenocarcinoma · score 0.37
- Endometrial Endometrioid Adenocarcinoma · score 0.37
- bile duct carcinoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q07812-F1 | alphafold | PREDICTED | 85.95 | — |
Amino-acid sequence (192 residues)
MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG EAPELALDPV PQDASTKKLS ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAADMF SDGNFNWGRV VALFYFASKL VLKALCTKVP ELIRTIMGWT LDFLRERLLG WIQDQGGWDG LLSYFGTPTW QTVTIFVAGV LTASLTIWKK MG
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