About Kinesin light chain 1
Kinesin light chain 1 (KLC1) is a protein
from Homo sapiens identified by UniProt accession
Q07866, 573 residues long.
MolForge cross-references it against 0 known binders and
128 disease associations.
Target properties
| Protein name | Kinesin light chain 1 |
|---|
| UniProt accession | Q07866 |
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| Gene | KLC1 |
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| Organism | Homo sapiens |
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| Length | 573 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (128)
Diseases linked to this target (Open Targets).
- mitochondrial complex 4 deficiency, nuclear type 17 · score 0.52
- cancer · score 0.46
- neurodegenerative disease · score 0.45
- mitochondrial complex IV deficiency, nuclear type 22 · score 0.43
- leigh syndrome due to mitochondrial complex iv deficiency · score 0.43
- blood protein measurement · score 0.31
- schizophrenia · score 0.22
- self reported educational attainment · score 0.21
- genetic disorder · score 0.19
- cutaneous melanoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q07866-F1 | alphafold | PREDICTED | 74.97 | — |
Amino-acid sequence (573 residues)
MYDNMSTMVY IKEDKLEKLT QDEIISKTKQ VIQGLEALKN EHNSILQSLL ETLKCLKKDD ESNLVEEKSN MIRKSLEMLE LGLSEAQVMM ALSNHLNAVE SEKQKLRAQV RRLCQENQWL RDELANTQQK LQKSEQSVAQ LEEEKKHLEF MNQLKKYDDD ISPSEDKDTD STKEPLDDLF PNDEDDPGQG IQQQHSSAAA AAQQGGYEIP ARLRTLHNLV IQYASQGRYE VAVPLCKQAL EDLEKTSGHD HPDVATMLNI LALVYRDQNK YKDAANLLND ALAIREKTLG KDHPAVAATL NNLAVLYGKR GKYKEAEPLC KRALEIREKV LGKDHPDVAK QLNNLALLCQ NQGKYEEVEY YYQRALEIYQ TKLGPDDPNV AKTKNNLASC YLKQGKFKQA ETLYKEILTR AHEREFGSVD DENKPIWMHA EEREECKGKQ KDGTSFGEYG GWYKACKVDS PTVTTTLKNL GALYRRQGKF EAAETLEEAA MRSRKQGLDN VHKQRVAEVL NDPENMEKRR SRESLNVDVV KYESGPDGGE EVSMSVEWNG GVSGRASFCG KRQQQQWPGR RHR
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