About Serine/arginine-rich splicing factor 1
Serine/arginine-rich splicing factor 1 (SRSF1) is a protein
from Homo sapiens identified by UniProt accession
Q07955, 248 residues long.
MolForge cross-references it against 0 known binders and
258 disease associations.
Target properties
| Protein name | Serine/arginine-rich splicing factor 1 |
|---|
| UniProt accession | Q07955 |
|---|
| Gene | SRSF1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 248 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (258)
Diseases linked to this target (Open Targets).
- Neurodevelopmental delay · score 0.54
- Intellectual disability · score 0.53
- neurodegenerative disease · score 0.50
- chronic lymphocytic leukemia · score 0.23
- genetic disorder · score 0.16
- autism spectrum disorder · score 0.12
- cancer · score 0.10
- hepatocellular carcinoma · score 0.10
- body mass index · score 0.09
- Miyoshi myopathy · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q07955-F1 | alphafold | PREDICTED | 70.82 | — |
Amino-acid sequence (248 residues)
MSGGGVIRGP AGNNDCRIYV GNLPPDIRTK DIEDVFYKYG AIRDIDLKNR RGGPPFAFVE FEDPRDAEDA VYGRDGYDYD GYRLRVEFPR SGRGTGRGGG GGGGGGAPRG RYGPPSRRSE NRVVVSGLPP SGSWQDLKDH MREAGDVCYA DVYRDGTGVV EFVRKEDMTY AVRKLDNTKF RSHEGETAYI RVKVDGPRSP SYGRSRSRSR SRSRSRSRSN SRSRSYSPRR SRGSPRYSPR HSRSRSRT
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