Rho GTPase-activating protein 1 (ARHGAP1)

About Rho GTPase-activating protein 1

Rho GTPase-activating protein 1 (ARHGAP1) is a protein from Homo sapiens identified by UniProt accession Q07960, 439 residues long. MolForge cross-references it against 0 known binders and 128 disease associations.

Target properties

Protein name	Rho GTPase-activating protein 1
UniProt accession	Q07960
Gene	ARHGAP1
Organism	Homo sapiens
Length	439 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (128)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.32
Parkinson disease · score 0.22
Alzheimer disease · score 0.22
multiple sclerosis · score 0.22
lysosomal storage disease · score 0.22
glucose measurement · score 0.18
insulin measurement · score 0.16
Familial exudative vitreoretinopathy · score 0.14
cor pulmonale · score 0.11
femoral neck bone mineral density · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q07960-F1	alphafold	PREDICTED	82.02	—

Amino-acid sequence (439 residues)

MDPLSELQDD LTLDDTSEAL NQLKLASIDE KNWPSDEMPD FPKSDDSKSS SPELVTHLKW DDPYYDIARH QIVEVAGDDK YGRKIIVFSA CRMPPSHQLD HSKLLGYLKH TLDQYVESDY TLLYLHHGLT SDNKPSLSWL RDAYREFDRK YKKNIKALYI VHPTMFIKTL LILFKPLISF KFGQKIFYVN YLSELSEHVK LEQLGIPRQV LKYDDFLKST QKSPATAPKP MPPRPPLPNQ QFGVSLQHLQ EKNPEQEPIP IVLRETVAYL QAHALTTEGI FRRSANTQVV REVQQKYNMG LPVDFDQYNE LHLPAVILKT FLRELPEPLL TFDLYPHVVG FLNIDESQRV PATLQVLQTL PEENYQVLRF LTAFLVQISA HSDQNKMTNT NLAVVFGPNL LWAKDAAITL KAINPINTFT KFLLDHQGEL FPSPDPSGL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards