About 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1) is a protein
from Homo sapiens identified by UniProt accession
Q07973, 514 residues long.
MolForge cross-references it against 0 known binders and
347 disease associations.
Target properties
| Protein name | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial |
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| UniProt accession | Q07973 |
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| Gene | CYP24A1 |
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| Organism | Homo sapiens |
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| Length | 514 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (347)
Diseases linked to this target (Open Targets).
- Autosomal recessive infantile hypercalcemia · score 0.76
- hypercalcemia, infantile · score 0.57
- calcium measurement · score 0.50
- neurodegenerative disease · score 0.48
- vitamin D measurement · score 0.47
- blood phosphate measurement · score 0.44
- atopic eczema · score 0.44
- multiple sclerosis · score 0.41
- serum urea measurement · score 0.40
- alkaline phosphatase measurement · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q07973-F1 | alphafold | PREDICTED | 88.61 | — |
Amino-acid sequence (514 residues)
MSSPISKSRS LAAFLQQLRS PRQPPRLVTS TAYTSPQPRE VPVCPLTAGG ETQNAAALPG PTSWPLLGSL LQILWKGGLK KQHDTLVEYH KKYGKIFRMK LGSFESVHLG SPCLLEALYR TESAYPQRLE IKPWKAYRDY RKEGYGLLIL EGEDWQRVRS AFQKKLMKPG EVMKLDNKIN EVLADFMGRI DELCDERGHV EDLYSELNKW SFESICLVLY EKRFGLLQKN AGDEAVNFIM AIKTMMSTFG RMMVTPVELH KSLNTKVWQD HTLAWDTIFK SVKACIDNRL EKYSQQPSAD FLCDIYHQNR LSKKELYAAV TELQLAAVET TANSLMWILY NLSRNPQVQQ KLLKEIQSVL PENQVPRAED LRNMPYLKAC LKESMRLTPS VPFTTRTLDK ATVLGEYALP KGTVLMLNTQ VLGSSEDNFE DSSQFRPERW LQEKEKINPF AHLPFGVGKR MCIGRRLAEL QLHLALCWIV RKYDIQATDN EPVEMLHSGT LVPSRELPIA FCQR
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