About Protein-glutamine gamma-glutamyltransferase E
Protein-glutamine gamma-glutamyltransferase E (TGM3) is a protein
from Homo sapiens identified by UniProt accession
Q08188, 693 residues long.
MolForge cross-references it against 0 known binders and
164 disease associations.
Target properties
| Protein name | Protein-glutamine gamma-glutamyltransferase E |
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| UniProt accession | Q08188 |
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| Gene | TGM3 |
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| Organism | Homo sapiens |
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| Length | 693 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (164)
Diseases linked to this target (Open Targets).
- basal cell carcinoma · score 0.49
- uncombable hair syndrome · score 0.47
- non-melanoma skin carcinoma · score 0.44
- keratinocyte carcinoma · score 0.42
- skin cancer · score 0.41
- skin carcinoma · score 0.36
- cancer · score 0.33
- skin neoplasm · score 0.31
- dimethylglycine measurement · score 0.15
- ringed hair disease · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q08188-F1 | alphafold | PREDICTED | 95.88 | — |
Amino-acid sequence (693 residues)
MAALGVQSIN WQTAFNRQAH HTDKFSSQEL ILRRGQNFQV LMIMNKGLGS NERLEFIVST GPYPSESAMT KAVFPLSNGS SGGWSAVLQA SNGNTLTISI SSPASAPIGR YTMALQIFSQ GGISSVKLGT FILLFNPWLN VDSVFMGNHA EREEYVQEDA GIIFVGSTNR IGMIGWNFGQ FEEDILSICL SILDRSLNFR RDAATDVASR NDPKYVGRVL SAMINSNDDN GVLAGNWSGT YTGGRDPRSW NGSVEILKNW KKSGFSPVRY GQCWVFAGTL NTALRSLGIP SRVITNFNSA HDTDRNLSVD VYYDPMGNPL DKGSDSVWNF HVWNEGWFVR SDLGPSYGGW QVLDATPQER SQGVFQCGPA SVIGVREGDV QLNFDMPFIF AEVNADRITW LYDNTTGKQW KNSVNSHTIG RYISTKAVGS NARMDVTDKY KYPEGSDQER QVFQKALGKL KPNTPFAATS SMGLETEEQE PSIIGKLKVA GMLAVGKEVN LVLLLKNLSR DTKTVTVNMT AWTIIYNGTL VHEVWKDSAT MSLDPEEEAE HPIKISYAQY EKYLKSDNMI RITAVCKVPD ESEVVVERDI ILDNPTLTLE VLNEARVRKP VNVQMLFSNP LDEPVRDCVL MVEGSGLLLG NLKIDVPTLG PKEGSRVRFD ILPSRSGTKQ LLADFSCNKF PAIKAMLSID VAE
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