About Protein phosphatase 3 catalytic subunit alpha
Protein phosphatase 3 catalytic subunit alpha (PPP3CA) is a protein
from Homo sapiens identified by UniProt accession
Q08209, 521 residues long.
MolForge cross-references it against 0 known binders and
280 disease associations.
Target properties
| Protein name | Protein phosphatase 3 catalytic subunit alpha |
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| UniProt accession | Q08209 |
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| Gene | PPP3CA |
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| Organism | Homo sapiens |
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| Length | 521 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (280)
Diseases linked to this target (Open Targets).
- epileptic encephalopathy, infantile or early childhood, 1 · score 0.77
- infantile epileptic encephalopathy · score 0.73
- arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development · score 0.70
- lupus nephritis · score 0.53
- genetic disorder · score 0.44
- systolic blood pressure · score 0.42
- diastolic blood pressure · score 0.42
- Seizure · score 0.37
- immune system disease · score 0.37
- undetermined early-onset epileptic encephalopathy · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q08209-F1 | alphafold | PREDICTED | 85.47 | — |
Amino-acid sequence (521 residues)
MSEPKAIDPK LSTTDRVVKA VPFPPSHRLT AKEVFDNDGK PRVDILKAHL MKEGRLEESV ALRIITEGAS ILRQEKNLLD IDAPVTVCGD IHGQFFDLMK LFEVGGSPAN TRYLFLGDYV DRGYFSIECV LYLWALKILY PKTLFLLRGN HECRHLTEYF TFKQECKIKY SERVYDACMD AFDCLPLAAL MNQQFLCVHG GLSPEINTLD DIRKLDRFKE PPAYGPMCDI LWSDPLEDFG NEKTQEHFTH NTVRGCSYFY SYPAVCEFLQ HNNLLSILRA HEAQDAGYRM YRKSQTTGFP SLITIFSAPN YLDVYNNKAA VLKYENNVMN IRQFNCSPHP YWLPNFMDVF TWSLPFVGEK VTEMLVNVLN ICSDDELGSE EDGFDGATAA ARKEVIRNKI RAIGKMARVF SVLREESESV LTLKGLTPTG MLPSGVLSGG KQTLQSATVE AIEADEAIKG FSPQHKITSF EEAKGLDRIN ERMPPRRDAM PSDANLNSIN KALTSETNGT DSNGSNSSNI Q
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