About Zeta-crystallin
Zeta-crystallin (CRYZ) is a protein
from Homo sapiens identified by UniProt accession
Q08257, 329 residues long.
MolForge cross-references it against 0 known binders and
49 disease associations.
Target properties
| Protein name | Zeta-crystallin |
|---|
| UniProt accession | Q08257 |
|---|
| Gene | CRYZ |
|---|
| Organism | Homo sapiens |
|---|
| Length | 329 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (49)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.35
- blood protein measurement · score 0.35
- heel bone mineral density · score 0.26
- amyotrophic lateral sclerosis · score 0.20
- resistin measurement · score 0.20
- adolescent idiopathic scoliosis · score 0.17
- neurofibrillary tangles measurement · score 0.07
- axial length measurement · score 0.01
- hepatocellular carcinoma · score 0.01
- cancer · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q08257-F1 | alphafold | PREDICTED | 96.86 | — |
Amino-acid sequence (329 residues)
MATGQKLMRA VRVFEFGGPE VLKLRSDIAV PIPKDHQVLI KVHACGVNPV ETYIRSGTYS RKPLLPYTPG SDVAGVIEAV GDNASAFKKG DRVFTSSTIS GGYAEYALAA DHTVYKLPEK LDFKQGAAIG IPYFTAYRAL IHSACVKAGE SVLVHGASGG VGLAACQIAR AYGLKILGTA GTEEGQKIVL QNGAHEVFNH REVNYIDKIK KYVGEKGIDI IIEMLANVNL SKDLSLLSHG GRVIVVGSRG TIEINPRDTM AKESSIIGVT LFSSTKEEFQ QYAAALQAGM EIGWLKPVIG SQYPLEKVAE AHENIIHGSG ATGKMILLL
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