About Voltage-dependent L-type calcium channel subunit beta-2
Voltage-dependent L-type calcium channel subunit beta-2 (CACNB2) is a protein
from Homo sapiens identified by UniProt accession
Q08289, 660 residues long.
MolForge cross-references it against 0 known binders and
167 disease associations.
Target properties
| Protein name | Voltage-dependent L-type calcium channel subunit beta-2 |
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| UniProt accession | Q08289 |
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| Gene | CACNB2 |
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| Organism | Homo sapiens |
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| Length | 660 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (167)
Diseases linked to this target (Open Targets).
- cardiovascular disease · score 0.58
- Brugada syndrome · score 0.53
- systolic blood pressure · score 0.52
- diastolic blood pressure · score 0.51
- hypertension · score 0.50
- body mass index · score 0.50
- schizophrenia · score 0.47
- alcohol drinking · score 0.47
- aspartate aminotransferase measurement · score 0.45
- white matter microstructure measurement · score 0.43
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q08289-F1 | alphafold | PREDICTED | 65.43 | — |
Amino-acid sequence (660 residues)
MVQRDMSKSP PTAAAAVAQE IQMELLENVA PAGALGAAAQ SYGKGARRKN RFKGSDGSTS SDTTSNSFVR QGSADSYTSR PSDSDVSLEE DREAVRREAE RQAQAQLEKA KTKPVAFAVR TNVSYSAAHE DDVPVPGMAI SFEAKDFLHV KEKFNNDWWI GRLVKEGCEI GFIPSPVKLE NMRLQHEQRA KQGKFYSSKS GGNSSSSLGD IVPSSRKSTP PSSAIDIDAT GLDAEENDIP ANHRSPKPSA NSVTSPHSKE KRMPFFKKTE HTPPYDVVPS MRPVVLVGPS LKGYEVTDMM QKALFDFLKH RFEGRISITR VTADISLAKR SVLNNPSKHA IIERSNTRSS LAEVQSEIER IFELARTLQL VVLDADTINH PAQLSKTSLA PIIVYVKISS PKVLQRLIKS RGKSQAKHLN VQMVAADKLA QCPPELFDVI LDENQLEDAC EHLADYLEAY WKATHPPSSS LPNPLLSRTL ATSSLPLSPT LASNSQGSQG DQRTDRSAPI RSASQAEEEP SVEPVKKSQH RSSSSAPHHN HRSGTSRGLS RQETFDSETQ ESRDSAYVEP KEDYSHDHVD HYASHRDHNH RDETHGSSDH RHRESRHRSR DVDREQDHNE CNKQRSRHKS KDRYCEKDGE VISKKRNEAG EWNRDVYIRQ
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