Interleukin-10 receptor subunit beta (IL10RB)

About Interleukin-10 receptor subunit beta

Interleukin-10 receptor subunit beta (IL10RB) is a protein from Homo sapiens identified by UniProt accession Q08334, 325 residues long. MolForge cross-references it against 0 known binders and 346 disease associations.

Target properties

Protein name	Interleukin-10 receptor subunit beta
UniProt accession	Q08334
Gene	IL10RB
Organism	Homo sapiens
Length	325 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (346)

Diseases linked to this target (Open Targets).

inflammatory bowel disease 25 · score 0.73
Autosomal recessive early-onset inflammatory bowel disease · score 0.65
immune dysregulation-inflammatory bowel disease-arthritis-recurrent infections syndrome · score 0.55
inflammatory bowel disease · score 0.42
hepatitis C virus infection · score 0.39
ulcerative colitis · score 0.37
COVID-19 · score 0.37
interleukin-10 receptor B measurement · score 0.36
hepatitis D virus infection · score 0.29
chronic hepatitis C virus infection · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q08334-F1	alphafold	PREDICTED	82.14	—

Amino-acid sequence (325 residues)

MAWSLGSWLG GCLLVSALGM VPPPENVRMN SVNFKNILQW ESPAFAKGNL TFTAQYLSYR IFQDKCMNTT LTECDFSSLS KYGDHTLRVR AEFADEHSDW VNITFCPVDD TIIGPPGMQV EVLADSLHMR FLAPKIENEY ETWTMKNVYN SWTYNVQYWK NGTDEKFQIT PQYDFEVLRN LEPWTTYCVQ VRGFLPDRNK AGEWSEPVCE QTTHDETVPS WMVAVILMAS VFMVCLALLG CFALLWCVYK KTKYAFSPRN SLPQHLKEFL GHPHHNTLLF FSFPLSDEND VFDKLSVIAE DSESGKQNPG DSCSLGTPPG QGPQS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards