Lysyl oxidase homolog 1 (LOXL1)

About Lysyl oxidase homolog 1

Lysyl oxidase homolog 1 (LOXL1) is a protein from Homo sapiens identified by UniProt accession Q08397, 574 residues long. MolForge cross-references it against 0 known binders and 288 disease associations.

Target properties

Protein name	Lysyl oxidase homolog 1
UniProt accession	Q08397
Gene	LOXL1
Organism	Homo sapiens
Length	574 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (288)

Diseases linked to this target (Open Targets).

exfoliation syndrome · score 0.48
open-angle glaucoma · score 0.39
BMI-adjusted waist circumference · score 0.38
glaucoma · score 0.38
vital capacity · score 0.37
body height · score 0.35
body fat distribution · score 0.34
BMI-adjusted waist-hip ratio · score 0.33
forced expiratory volume · score 0.33
physical activity measurement · score 0.32

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q08397-F1	alphafold	PREDICTED	59.10	—

Amino-acid sequence (574 residues)

MALARGSRQL GALVWGACLC VLVHGQQAQP GQGSDPARWR QLIQWENNGQ VYSLLNSGSE YVPAGPQRSE SSSRVLLAGA PQAQQRRSHG SPRRRQAPSL PLPGRVGSDT VRGQARHPFG FGQVPDNWRE VAVGDSTGMA RARTSVSQQR HGGSASSVSA SAFASTYRQQ PSYPQQFPYP QAPFVSQYEN YDPASRTYDQ GFVYYRPAGG GVGAGAAAVA SAGVIYPYQP RARYEEYGGG EELPEYPPQG FYPAPERPYV PPPPPPPDGL DRRYSHSLYS EGTPGFEQAY PDPGPEAAQA HGGDPRLGWY PPYANPPPEA YGPPRALEPP YLPVRSSDTP PPGGERNGAQ QGRLSVGSVY RPNQNGRGLP DLVPDPNYVQ ASTYVQRAHL YSLRCAAEEK CLASTAYAPE ATDYDVRVLL RFPQRVKNQG TADFLPNRPR HTWEWHSCHQ HYHSMDEFSH YDLLDAATGK KVAEGHKASF CLEDSTCDFG NLKRYACTSH TQGLSPGCYD TYNADIDCQW IDITDVQPGN YILKVHVNPK YIVLESDFTN NVVRCNIHYT GRYVSATNCK IVQS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards