About Peroxisomal bifunctional enzyme
Peroxisomal bifunctional enzyme (EHHADH) is a protein
from Homo sapiens identified by UniProt accession
Q08426, 723 residues long.
MolForge cross-references it against 0 known binders and
152 disease associations.
Target properties
| Protein name | Peroxisomal bifunctional enzyme |
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| UniProt accession | Q08426 |
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| Gene | EHHADH |
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| Organism | Homo sapiens |
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| Length | 723 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (152)
Diseases linked to this target (Open Targets).
- primary Fanconi syndrome · score 0.43
- Fanconi renotubular syndrome 1 · score 0.40
- d-bifunctional protein deficiency · score 0.37
- PHF-tau measurement · score 0.27
- metabolic acidosis · score 0.23
- Metabolic acidosis · score 0.23
- drug use measurement · score 0.17
- chronic kidney disease · score 0.15
- type 2 diabetes mellitus · score 0.11
- sex hormone-binding globulin measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q08426-F1 | alphafold | PREDICTED | 94.98 | — |
Amino-acid sequence (723 residues)
MAEYTRLHNA LALIRLRNPP VNAISTTLLR DIKEGLQKAV IDHTIKAIVI CGAEGKFSAG ADIRGFSAPR TFGLTLGHVV DEIQRNEKPV VAAIQGMAFG GGLELALGCH YRIAHAEAQV GLPEVTLGLL PGARGTQLLP RLTGVPAALD LITSGRRILA DEALKLGILD KVVNSDPVEE AIRFAQRVSD QPLESRRLCN KPIQSLPNMD SIFSEALLKM RRQHPGCLAQ EACVRAVQAA VQYPYEVGIK KEEELFLYLL QSGQARALQY AFFAERKANK WSTPSGASWK TASARPVSSV GVVGLGTMGR GIVISFARAR IPVIAVDSDK NQLATANKMI TSVLEKEASK MQQSGHPWSG PKPRLTSSVK ELGGVDLVIE AVFEEMSLKK QVFAELSAVC KPEAFLCTNT SALDVDEIAS STDRPHLVIG THFFSPAHVM KLLEVIPSQY SSPTTIATVM NLSKKIKKIG VVVGNCFGFV GNRMLNPYYN QAYFLLEEGS KPEEVDQVLE EFGFKMGPFR VSDLAGLDVG WKSRKGQGLT GPTLLPGTPA RKRGNRRYCP IPDVLCELGR FGQKTGKGWY QYDKPLGRIH KPDPWLSKFL SRYRKTHHIE PRTISQDEIL ERCLYSLINE AFRILGEGIA ASPEHIDVVY LHGYGWPRHK GGPMFYASTV GLPTVLEKLQ KYYRQNPDIP QLEPSDYLKK LASQGNPPLK EWQSLAGSPS SKL
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