Lactadherin (MFGE8)

About Lactadherin

Lactadherin (MFGE8) is a protein from Homo sapiens identified by UniProt accession Q08431, 387 residues long. MolForge cross-references it against 0 known binders and 293 disease associations.

Target properties

Protein name	Lactadherin
UniProt accession	Q08431
Gene	MFGE8
Organism	Homo sapiens
Length	387 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (293)

Diseases linked to this target (Open Targets).

AL amyloidosis · score 0.46
lactadherin measurement · score 0.37
blood protein measurement · score 0.36
alkaline phosphatase measurement · score 0.36
coronary artery disease · score 0.35
Myocardial Ischemia · score 0.30
body height · score 0.30
myocardial infarction · score 0.29
angina pectoris · score 0.27
coronary atherosclerosis · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q08431-F1	alphafold	PREDICTED	87.26	—

Amino-acid sequence (387 residues)

MPRPRLLAAL CGALLCAPSL LVALDICSKN PCHNGGLCEE ISQEVRGDVF PSYTCTCLKG YAGNHCETKC VEPLGLENGN IANSQIAASS VRVTFLGLQH WVPELARLNR AGMVNAWTPS SNDDNPWIQV NLLRRMWVTG VVTQGASRLA SHEYLKAFKV AYSLNGHEFD FIHDVNKKHK EFVGNWNKNA VHVNLFETPV EAQYVRLYPT SCHTACTLRF ELLGCELNGC ANPLGLKNNS IPDKQITASS SYKTWGLHLF SWNPSYARLD KQGNFNAWVA GSYGNDQWLQ VDLGSSKEVT GIITQGARNF GSVQFVASYK VAYSNDSANW TEYQDPRTGS SKIFPGNWDN HSHKKNLFET PILARYVRIL PVAWHNRIAL RLELLGC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards