About Pseudouridine-5'-phosphatase
Pseudouridine-5'-phosphatase (PUDP) is a protein
from Homo sapiens identified by UniProt accession
Q08623, 228 residues long.
MolForge cross-references it against 0 known binders and
62 disease associations.
Target properties
| Protein name | Pseudouridine-5'-phosphatase |
|---|
| UniProt accession | Q08623 |
|---|
| Gene | PUDP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 228 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (62)
Diseases linked to this target (Open Targets).
- cutaneous melanoma · score 0.12
- neoplasm · score 0.08
- hepatocellular carcinoma · score 0.07
- Cataract-microcornea syndrome · score 0.05
- MODY · score 0.05
- early-onset non-syndromic cataract · score 0.05
- Cataract with Y-shaped suture opacities · score 0.05
- Familial ocular anterior segment mesenchymal dysgenesis · score 0.05
- Total congenital cataract · score 0.05
- juvenile cataract-microcornea-renal glucosuria syndrome · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q08623-F1 | alphafold | PREDICTED | 97.44 | — |
Amino-acid sequence (228 residues)
MAAPPQPVTH LIFDMDGLLL DTERLYSVVF QEICNRYDKK YSWDVKSLVM GKKALEAAQI IIDVLQLPMS KEELVEESQT KLKEVFPTAA LMPGAEKLII HLRKHGIPFA LATSSGSASF DMKTSRHKEF FSLFSHIVLG DDPEVQHGKP DPDIFLACAK RFSPPPAMEK CLVFEDAPNG VEAALAAGMQ VVMVPDGNLS RDLTTKATLV LNSLQDFQPE LFGLPSYE
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