Leukocyte surface antigen CD47 (CD47)

About Leukocyte surface antigen CD47

Leukocyte surface antigen CD47 (CD47) is a protein from Homo sapiens identified by UniProt accession Q08722, 323 residues long. MolForge cross-references it against 0 known binders and 716 disease associations.

Target properties

Protein name	Leukocyte surface antigen CD47
UniProt accession	Q08722
Gene	CD47
Organism	Homo sapiens
Length	323 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (716)

Diseases linked to this target (Open Targets).

bipolar disorder · score 0.39
mathematical ability · score 0.33
Abnormality of refraction · score 0.29
Tourette syndrome · score 0.28
self reported educational attainment · score 0.27
smoking behaviour measurement · score 0.26
Eczematoid dermatitis · score 0.24
body mass index · score 0.22
cognitive function measurement · score 0.21
acute myeloid leukemia · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q08722-F1	alphafold	PREDICTED	86.31	—

Amino-acid sequence (323 residues)

MWPLVAALLL GSACCGSAQL LFNKTKSVEF TFCNDTVVIP CFVTNMEAQN TTEVYVKWKF KGRDIYTFDG ALNKSTVPTD FSSAKIEVSQ LLKGDASLKM DKSDAVSHTG NYTCEVTELT REGETIIELK YRVVSWFSPN ENILIVIFPI FAILLFWGQF GIKTLKYRSG GMDEKTIALL VAGLVITVIV IVGAILFVPG EYSLKNATGL GLIVTSTGIL ILLHYYVFST AIGLTSFVIA ILVIQVIAYI LAVVGLSLCI AACIPMHGPL LISGLSILAL AQLLGLVYMK FVASNQKTIQ PPRKAVEEPL NAFKESKGMM NDE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards