About Acyl-coenzyme A synthetase ACSM1, mitochondrial
Acyl-coenzyme A synthetase ACSM1, mitochondrial (ACSM1) is a protein
from Homo sapiens identified by UniProt accession
Q08AH1, 577 residues long.
MolForge cross-references it against 0 known binders and
46 disease associations.
Target properties
| Protein name | Acyl-coenzyme A synthetase ACSM1, mitochondrial |
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| UniProt accession | Q08AH1 |
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| Gene | ACSM1 |
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| Organism | Homo sapiens |
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| Length | 577 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (46)
Diseases linked to this target (Open Targets).
- cutaneous melanoma · score 0.25
- lung adenocarcinoma · score 0.25
- glioblastoma multiforme · score 0.16
- erythrocyte count · score 0.15
- squamous cell lung carcinoma · score 0.14
- head and neck squamous cell carcinoma · score 0.14
- urate measurement · score 0.13
- urinary metabolite measurement · score 0.12
- adolescent idiopathic scoliosis · score 0.12
- mean corpuscular volume · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q08AH1-F1 | alphafold | PREDICTED | 88.99 | — |
Amino-acid sequence (577 residues)
MQWLMRFRTL WGIHKSFHNI HPAPSQLRCR SLSEFGAPRW NDYEVPEEFN FASYVLDYWA QKEKEGKRGP NPAFWWVNGQ GDEVKWSFRE MGDLTRRVAN VFTQTCGLQQ GDHLALMLPR VPEWWLVAVG CMRTGIIFIP ATILLKAKDI LYRLQLSKAK GIVTIDALAS EVDSIASQCP SLKTKLLVSD HSREGWLDFR SLVKSASPEH TCVKSKTLDP MVIFFTSGTT GFPKMAKHSH GLALQPSFPG SRKLRSLKTS DVSWCLSDSG WIVATIWTLV EPWTAGCTVF IHHLPQFDTK VIIQTLLKYP INHFWGVSSI YRMILQQDFT SIRFPALEHC YTGGEVVLPK DQEEWKRRTG LLLYENYGQS ETGLICATYW GMKIKPGFMG KATPPYDVQV IDDKGSILPP NTEGNIGIRI KPVRPVSLFM CYEGDPEKTA KVECGDFYNT GDRGKMDEEG YICFLGRSDD IINASGYRIG PAEVESALVE HPAVAESAVV GSPDPIRGEV VKAFIVLTPQ FLSHDKDQLT KELQQHVKSV TAPYKYPRKV EFVSELPKTI TGKIERKELR KKETGQM
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