About Acyl-coenzyme A synthetase ACSM2A, mitochondrial
Acyl-coenzyme A synthetase ACSM2A, mitochondrial (ACSM2A) is a protein
from Homo sapiens identified by UniProt accession
Q08AH3, 577 residues long.
MolForge cross-references it against 0 known binders and
31 disease associations.
Target properties
| Protein name | Acyl-coenzyme A synthetase ACSM2A, mitochondrial |
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| UniProt accession | Q08AH3 |
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| Gene | ACSM2A |
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| Organism | Homo sapiens |
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| Length | 577 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (31)
Diseases linked to this target (Open Targets).
- serum metabolite measurement · score 0.42
- blood metabolite measurement · score 0.40
- urinary metabolite measurement · score 0.32
- protein measurement · score 0.27
- cutaneous melanoma · score 0.25
- lung adenocarcinoma · score 0.25
- glioblastoma multiforme · score 0.16
- squamous cell lung carcinoma · score 0.15
- head and neck squamous cell carcinoma · score 0.15
- drug use measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q08AH3-F1 | alphafold | PREDICTED | 91.43 | — |
Amino-acid sequence (577 residues)
MHWLRKVQGL CTLWGTQMSS RTLYINSRQL VSLQWGHQEV PAKFNFASDV LDHWADMEKA GKRLPSPALW WVNGKGKELM WNFRELSENS QQAANVLSGA CGLQRGDRVA VVLPRVPEWW LVILGCIRAG LIFMPGTIQM KSTDILYRLQ MSKAKAIVAG DEVIQEVDTV ASECPSLRIK LLVSEKSCDG WLNFKKLLNE ASTTHHCVET GSQEASAIYF TSGTSGLPKM AEHSYSSLGL KAKMDAGWTG LQASDIMWTI SDTGWILNIL CSLMEPWALG ACTFVHLLPK FDPLVILKTL SSYPIKSMMG APIVYRMLLQ QDLSSYKFPH LQNCVTVGES LLPETLENWR AQTGLDIRES YGQTETGLTC MVSKTMKIKP GYMGTAASCY DVQIIDDKGN VLPPGTEGDI GIRVKPIRPI GIFSGYVDNP DKTAANIRGD FWLLGDRGIK DEDGYFQFMG RANDIINSSG YRIGPSEVEN ALMEHPAVVE TAVISSPDPV RGEVVKAFVV LASQFLSHDP EQLTKELQQH VKSVTAPYKY PRKIEFVLNL PKTVTGKIQR AKLRDKEWKM SGKARAQ
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