Protein mab-21-like 4 (MAB21L4)

About Protein mab-21-like 4

Protein mab-21-like 4 (MAB21L4) is a protein from Homo sapiens identified by UniProt accession Q08AI8, 447 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.

Target properties

Protein name	Protein mab-21-like 4
UniProt accession	Q08AI8
Gene	MAB21L4
Organism	Homo sapiens
Length	447 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (31)

Diseases linked to this target (Open Targets).

vital capacity · score 0.32
BMI-adjusted hip circumference · score 0.32
body height · score 0.30
urinary metabolite measurement · score 0.24
blood metabolite measurement · score 0.24
forced expiratory volume · score 0.16
joint hypermobility measurement · score 0.11
FEV/FVC ratio · score 0.08
sex hormone-binding globulin measurement · score 0.06
esophageal squamous cell carcinoma · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q08AI8-F1	alphafold	PREDICTED	84.35	—

Amino-acid sequence (447 residues)

MPAPALPTSA MAVQVPLWHH YLQAIRSREA PRAQDFQRAE NVLLTVLERV HALDPRFIVD YSRGLEAFQF ALRSSEDPMD MEVPLWVDAE ALLIEEPEAT QPEDGLELCH LGVPREGAGL ERWTTEDTFT ASSEGDAKCR GHIVPSKVLC VLKDLLVAAI VHCKHHSLIA PGSLNAASLR EEQLHLSLLV SSGWRTISFH VVPVVRRKLG APALEGVQQM PGFPEGSLRR ILSQGVDLVP ASAQLWRTST DYLLTRLLGE LGSLQGHRLD SLSILDRVNH ESWRDSGQTD GLTFGHLKMV LLWASVLFLA PEDWAELQGA VYRLLVVLLC CLATRKLPHF LHPQRNLLQG SGLDLGAIYQ RVEGFASQPE AALRIHATHL GRSPPPRIGS GLKALLQLPA SDPTYWATAY FDVLLDKFQV FNIQDKDRIS AMQSIFQKTR TLGGEES

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards