Sialic acid-binding Ig-like lectin 14 (SIGLEC14)

About Sialic acid-binding Ig-like lectin 14

Sialic acid-binding Ig-like lectin 14 (SIGLEC14) is a protein from Homo sapiens identified by UniProt accession Q08ET2, 396 residues long. MolForge cross-references it against 0 known binders and 106 disease associations.

Target properties

Protein name	Sialic acid-binding Ig-like lectin 14
UniProt accession	Q08ET2
Gene	SIGLEC14
Organism	Homo sapiens
Length	396 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (106)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.25
calcium measurement · score 0.21
sialic acid-binding Ig-like lectin 14 measurement · score 0.20
Red cell distribution width · score 0.20
pancreatic adenocarcinoma · score 0.18
protein measurement · score 0.18
basophil count · score 0.17
plasma plasminogen measurement · score 0.12
monocyte count · score 0.08
platelet component distribution width · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q08ET2-F1	alphafold	PREDICTED	83.43	—

Amino-acid sequence (396 residues)

MLPLLLLPLL WGGSLQEKPV YELQVQKSVT VQEGLCVLVP CSFSYPWRSW YSSPPLYVYW FRDGEIPYYA EVVATNNPDR RVKPETQGRF RLLGDVQKKN CSLSIGDARM EDTGSYFFRV ERGRDVKYSY QQNKLNLEVT ALIEKPDIHF LEPLESGRPT RLSCSLPGSC EAGPPLTFSW TGNALSPLDP ETTRSSELTL TPRPEDHGTN LTCQVKRQGA QVTTERTVQL NVSYAPQNLA ISIFFRNGTG TALRILSNGM SVPIQEGQSL FLACTVDSNP PASLSWFREG KALNPSQTSM SGTLELPNIG AREGGEFTCR VQHPLGSQHL SFILSVQRSS SSCICVTEKQ QGSWPLVLTL IRGALMGAGF LLTYGLTWIY YTRCGGPQQS RAERPG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards