About RNA cytosine C(5)-methyltransferase NSUN2
RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) is a protein
from Homo sapiens identified by UniProt accession
Q08J23, 767 residues long.
MolForge cross-references it against 0 known binders and
220 disease associations.
Target properties
| Protein name | RNA cytosine C(5)-methyltransferase NSUN2 |
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| UniProt accession | Q08J23 |
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| Gene | NSUN2 |
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| Organism | Homo sapiens |
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| Length | 767 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (220)
Diseases linked to this target (Open Targets).
- autosomal recessive non-syndromic intellectual disability · score 0.65
- genetic disorder · score 0.52
- neurodegenerative disease · score 0.46
- Dubowitz syndrome · score 0.37
- syndromic intellectual disability · score 0.37
- heel bone mineral density · score 0.33
- DNA methylation · score 0.24
- Intellectual disability · score 0.14
- Global developmental delay · score 0.12
- neoplasm · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q08J23-F1 | alphafold | PREDICTED | 78.08 | — |
Amino-acid sequence (767 residues)
MGRRSRGRRL QQQQRPEDAE DGAEGGGKRG EAGWEGGYPE IVKENKLFEH YYQELKIVPE GEWGQFMDAL REPLPATLRI TGYKSHAKEI LHCLKNKYFK ELEDLEVDGQ KVEVPQPLSW YPEELAWHTN LSRKILRKSP HLEKFHQFLV SETESGNISR QEAVSMIPPL LLNVRPHHKI LDMCAAPGSK TTQLIEMLHA DMNVPFPEGF VIANDVDNKR CYLLVHQAKR LSSPCIMVVN HDASSIPRLQ IDVDGRKEIL FYDRILCDVP CSGDGTMRKN IDVWKKWTTL NSLQLHGLQL RIATRGAEQL AEGGRMVYST CSLNPIEDEA VIASLLEKSE GALELADVSN ELPGLKWMPG ITQWKVMTKD GQWFTDWDAV PHSRHTQIRP TMFPPKDPEK LQAMHLERCL RILPHHQNTG GFFVAVLVKK SSMPWNKRQP KLQGKSAETR ESTQLSPADL TEGKPTDPSK LESPSFTGTG DTEIAHATED LENNGSKKDG VCGPPPSKKM KLFGFKEDPF VFIPEDDPLF PPIEKFYALD PSFPRMNLLT RTTEGKKRQL YMVSKELRNV LLNNSEKMKV INTGIKVWCR NNSGEEFDCA FRLAQEGIYT LYPFINSRII TVSMEDVKIL LTQENPFFRK LSSETYSQAK DLAKGSIVLK YEPDSANPDA LQCPIVLCGW RGKASIRTFV PKNERLHYLR MMGLEVLGEK KKEGVILTNE SAASTGQPDN DVTEGQRAGE PNSPDAEEAN SPDVTAGCDP AGVHPPR
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